| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | IREB2 | Ser157 | LQKAGKLsPVKVQPK | phosphorylation down-regulates | 18574241 | SIGNOR-179171 |
| CyclinB/CDK1 | IREB2 | Ser157 | LQKAGKLsPVKVQPK | phosphorylation down-regulates | 18574241 | SIGNOR-216888 |
| CDC14A | IREB2 | Ser157 | LQKAGKLsPVKVQPK | dephosphorylation up-regulates activity | 18574241 | SIGNOR-248829 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | IREB2 PSer157 | phosphorylation down-regulates ⊣ | IREB2 | 18574241 | SIGNOR-179171 |
| CyclinB/CDK1 | phosphorylation up-regulates → | IREB2 PSer157 | phosphorylation down-regulates ⊣ | IREB2 | 18574241 | SIGNOR-216888 |
| CDC14A | dephosphorylation down-regulates ⊣ | IREB2 PSer157 | dephosphorylation down-regulates ⊣ | IREB2 | 18574241 | SIGNOR-248829 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | IREB2 | SIGNOR-179171 |
| CyclinB/CDK1 | phosphorylation down-regulates | IREB2 | SIGNOR-216888 |
| CDC14A | dephosphorylation → up-regulates activity | IREB2 | SIGNOR-248829 |
