Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDKL5	SOX9	Ser199 View in OncoXplorer	ATEQTHIsPNAIFKA	phosphorylation down-regulates activity	32317630	SIGNOR-279457
GSK3B	SOX9	Thr236	GQSQGPPtPPTTPKT	phosphorylation down-regulates activity	27566146	SIGNOR-279725
ROCK1	SOX9	Ser181	YQPRRRKsVKNGQAE	phosphorylation up-regulates	20039424	SIGNOR-162643
ADCK5	SOX9	Ser181	YQPRRRKsVKNGQAE	phosphorylation up-regulates activity	32277958	SIGNOR-264567
PRKG2	SOX9	–		phosphorylation down-regulates activity	19543319	SIGNOR-278985
PRKACA	SOX9	Ser181	YQPRRRKsVKNGQAE	phosphorylation up-regulates	15889150	SIGNOR-137085
PRKACA	SOX9	Ser64	EPDLKKEsEEDKFPV	phosphorylation up-regulates	15889150	SIGNOR-137089

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDKL5	phosphorylation up-regulates →	SOX9 PSer199	phosphorylation down-regulates ⊣	SOX9	32317630	SIGNOR-279457
GSK3B	phosphorylation up-regulates →	SOX9 PThr236	phosphorylation down-regulates ⊣	SOX9	27566146	SIGNOR-279725
ROCK1	phosphorylation up-regulates →	SOX9 PSer181	phosphorylation up-regulates →	SOX9	20039424	SIGNOR-162643
ADCK5	phosphorylation up-regulates →	SOX9 PSer181	phosphorylation up-regulates →	SOX9	32277958	SIGNOR-264567
PRKACA	phosphorylation up-regulates →	SOX9 PSer181	phosphorylation up-regulates →	SOX9	15889150	SIGNOR-137085
PRKACA	phosphorylation up-regulates →	SOX9 PSer64	phosphorylation up-regulates →	SOX9	15889150	SIGNOR-137089

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDKL5	phosphorylation → down-regulates activity	SOX9	SIGNOR-279457
GSK3B	phosphorylation → down-regulates activity	SOX9	SIGNOR-279725
ROCK1	phosphorylation → up-regulates	SOX9	SIGNOR-162643
ADCK5	phosphorylation → up-regulates activity	SOX9	SIGNOR-264567
PRKG2	phosphorylation → down-regulates activity	SOX9	SIGNOR-278985
PRKACA	phosphorylation → up-regulates	SOX9	SIGNOR-137085
PRKACA	phosphorylation → up-regulates	SOX9	SIGNOR-137089