Entity Details

Name CSNK1D
ID P48730
Role kinase
Enzymatic Domains
Protein kinase 9-277
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CSNK1DPSEN2Ser9LTFMASDsEEEVCDEphosphorylation
unknown
8972483SIGNOR-250804
CSNK1DBACE1Ser498DDFADDIsLLKphosphorylation
unknown
11278841SIGNOR-250797
CSNK1DMAPTSer519SGYSSPGsPGTPGSRphosphorylation
down-regulates
14761950SIGNOR-121705
CSNK1DDCKphosphorylation
up-regulates activity
20637175SIGNOR-280233
CSNK1DERGphosphorylation
down-regulates activity
26344095SIGNOR-280234
CSNK1DKDRphosphorylation
down-regulates activity
22711876SIGNOR-280235
CSNK1DTP53Thr18EPPLSQEtFSDLWKLphosphorylation
up-regulates
10606744SIGNOR-73270
CSNK1DWWTR1Ser314SREQSTDsGLGLGCYphosphorylation
down-regulates
24715453SIGNOR-234438
CSNK1DYAP1Ser400SRDESTDsGLSMSSYphosphorylation
down-regulates
23431053SIGNOR-201143
CSNK1DYAP1Ser403ESTDSGLsMSSYSVPphosphorylation
down-regulates
24715453SIGNOR-230743
CSNK1DCDH1Ser844GSGSEAAsLSSLNSSphosphorylation
down-regulates activity
17353278SIGNOR-274046
CSNK1DPER2Ser480PVPHSGSsGYGSLGSphosphorylation
down-regulates quantity by destabilization
30425162SIGNOR-277420
CSNK1DGJA1Ser330AGSTISNsHAQPFDFphosphorylation
up-regulates activity
12270943SIGNOR-249331
CSNK1DWEE1Ser212SVKLRGSsLFMDTEKphosphorylation
down-regulates quantity by destabilization
24817118SIGNOR-276631
CSNK1DKIR3DL1Ser388RTANSEDsDEQDPEEphosphorylation
up-regulates
17911614SIGNOR-158125
CSNK1DLRP6Thr1493NPPPSPAtERSHYTMphosphorylation
up-regulates activity
35487243SIGNOR-275403
CSNK1DDVL2Thr224MSRFSSStEQSSASRphosphorylation
up-regulates
22609948SIGNOR-197551
CSNK1DPER2phosphorylation
down-regulates quantity by destabilization
11165242SIGNOR-268000
CSNK1DPER1phosphorylation
down-regulates quantity by destabilization
11165242SIGNOR-268001
CSNK1DMDM2Ser253SVEFEVEsLDSEDYSphosphorylation
down-regulates
20708156SIGNOR-167513
CSNK1DMAPRE1phosphorylation
up-regulates activity
22123863SIGNOR-279165
CSNK1DPSEN2Ser335YDSFGEPsYPEVFEPphosphorylation
up-regulates activity
9558331SIGNOR-250802
CSNK1DMDM2Ser262DSEDYSLsEEGQELSphosphorylation
down-regulates
12167711SIGNOR-91199
CSNK1DPSEN2Ser330MEEDSYDsFGEPSYPphosphorylation
up-regulates activity
9558331SIGNOR-250801
CSNK1DPER3phosphorylation
down-regulates quantity by destabilization
11865049SIGNOR-267998
CSNK1DGJA1Ser325NRMGQAGsTISNSHAphosphorylation
up-regulates activity
12270943SIGNOR-249329
CSNK1DMAPTSer721PVVSGDTsPRHLSNVphosphorylation
down-regulates
14761950SIGNOR-121713
CSNK1DMTSS1Ser322SSVSSHDsGFISQDAphosphorylation
down-regulates quantity by destabilization
24318128SIGNOR-276611
CSNK1DMDM2Ser121ESSDSGTsVSENRCHphosphorylation
down-regulates
20708156SIGNOR-167501
CSNK1DTP53Ser20PLSQETFsDLWKLLPphosphorylation
up-regulates
10734067SIGNOR-75889
CSNK1DNCOA3Ser601SDKESKEsSVEGAENphosphorylation
up-regulates
19339517SIGNOR-184946
CSNK1DKIR3DL1Ser385AGNRTANsEDSDEQDphosphorylation
up-regulates
17911614SIGNOR-158121
CSNK1DTP53Ser20PLSQETFsDLWKLLPphosphorylation
up-regulates
10606744SIGNOR-73266
CSNK1DLEF1phosphorylation
down-regulates
15747065SIGNOR-134494
CSNK1DAXIN1Ser46PASYSFCsGKGVGIKphosphorylation
up-regulates
12000790SIGNOR-87437
CSNK1DPSEN2Ser19EVCDERTsLMSAESPphosphorylation
unknown
8972483SIGNOR-250799
CSNK1DGJA1Ser328 GQAGSTIsNSHAQPFphosphorylation
up-regulates activity
12270943SIGNOR-249330
CSNK1DSMARCA4Ser31PGAMLGPsPGPSPGSphosphorylation
down-regulates quantity by destabilization
30177679SIGNOR-277408
CSNK1DDVL2Ser143FHPNVSSsHENLEPEphosphorylation
up-regulates
22609948SIGNOR-197547
CSNK1DPRH1Ser24QDLDEDVsQEDVPLVphosphorylation
up-regulates
10684652SIGNOR-75272
CSNK1DMDM2Ser269SEEGQELsDEDDEVYphosphorylation
down-regulates activity
12167711SIGNOR-91191
CSNK1DPPP5CThr362LFSEDGVtLDDIRKIphosphorylation
up-regulates activity
29141220SIGNOR-277373
CSNK1DYAP1Ser403ESTDSGLsMSSYSVPphosphorylation
down-regulates
23431053SIGNOR-201154
CSNK1DUHRF1Ser95SELSDTDsGCCLGQSphosphorylation
up-regulates
23297342SIGNOR-200349
CSNK1DGSK3B/Axin/APCphosphorylation
up-regulates
12000790SIGNOR-227970
CSNK1DDCKSer74EFEELTMsQKNGGNVphosphorylation
up-regulates activity
20637175SIGNOR-275799
CSNK1DHIF1ASer247KTFLSRHsLDMKFSYphosphorylation
down-regulates
20699359SIGNOR-167476
CSNK1DMDM2Ser118NQQESSDsGTSVSENphosphorylation
down-regulates
20708156SIGNOR-167497
CSNK1DPER1phosphorylation
down-regulates quantity by destabilization
11865049SIGNOR-267999
CSNK1DMDM2Ser262DSEDYSLsEEGQELSphosphorylation
down-regulates
20708156SIGNOR-167517
CSNK1DYAP1Ser400SRDESTDsGLSMSSYphosphorylation
down-regulates
24715453SIGNOR-230738
CSNK1DMDM2phosphorylation
down-regulates
20708156SIGNOR-167520
CSNK1DMAPTSer396DDKKAKTsTRSSAKTphosphorylation
down-regulates
14761950SIGNOR-121709
CSNK1DPSEN2Ser327DPEMEEDsYDSFGEPphosphorylation
up-regulates activity
9558331SIGNOR-250800
CSNK1DPSEN2Ser7sDSEEEVCphosphorylation
unknown
8972483SIGNOR-250803
CSNK1DSMARCA4Ser35LGPSPGPsPGSAHSMphosphorylation
down-regulates quantity by destabilization
30177679SIGNOR-277407
CSNK1DCDK5Ser159GIPVRCYsAEVVTLWphosphorylation
up-regulates activity
10500146SIGNOR-250798
CSNK1DMAPTThr522SSPGSPGtPGSRSRTphosphorylation
down-regulates
14761950SIGNOR-121717
CSNK1DCTNNB1Ser45GATTTAPsLSGKGNPphosphorylation
down-regulates
12000790SIGNOR-87441
CSNK1DTOP2BSer1132QNQHDDSsSDSGTPSphosphorylation
down-regulates quantity by destabilization
32015321SIGNOR-277509
CSNK1DLRP6Thr1479SSSSTKGtYFPAILNphosphorylation
up-regulates activity
35487243SIGNOR-275402
CSNK1DMDM2Ser246DSVSDQFsVEFEVESphosphorylation
down-regulates
20708156SIGNOR-167509
CSNK1DZNF322Ser396ELSPPHAsEASQMSphosphorylation
down-regulates quantity by destabilization
28581525SIGNOR-264892
CSNK1DMDM2Ser253SVEFEVEsLDSEDYSphosphorylation
down-regulates
12167711SIGNOR-91195
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CSNK1Dphosphorylation
up-regulates
PSEN2
PSer9
phosphorylation
down-regulates
PSEN28972483SIGNOR-250804
CSNK1Dphosphorylation
up-regulates
BACE1
PSer498
phosphorylation
down-regulates
BACE111278841SIGNOR-250797
CSNK1Dphosphorylation
up-regulates
MAPT
PSer519
phosphorylation
down-regulates
MAPT14761950SIGNOR-121705
CSNK1Dphosphorylation
up-regulates
TP53
PThr18
phosphorylation
up-regulates
TP5310606744SIGNOR-73270
CSNK1Dphosphorylation
up-regulates
WWTR1
PSer314
phosphorylation
down-regulates
WWTR124715453SIGNOR-234438
CSNK1Dphosphorylation
up-regulates
YAP1
PSer400
phosphorylation
down-regulates
YAP123431053SIGNOR-201143
CSNK1Dphosphorylation
up-regulates
YAP1
PSer403
phosphorylation
down-regulates
YAP124715453SIGNOR-230743
CSNK1Dphosphorylation
up-regulates
CDH1
PSer844
phosphorylation
down-regulates
CDH117353278SIGNOR-274046
CSNK1Dphosphorylation
up-regulates
PER2
PSer480
phosphorylation
down-regulates
PER230425162SIGNOR-277420
CSNK1Dphosphorylation
up-regulates
GJA1
PSer330
phosphorylation
up-regulates
GJA112270943SIGNOR-249331
CSNK1Dphosphorylation
up-regulates
WEE1
PSer212
phosphorylation
down-regulates
WEE124817118SIGNOR-276631
CSNK1Dphosphorylation
up-regulates
KIR3DL1
PSer388
phosphorylation
up-regulates
KIR3DL117911614SIGNOR-158125
CSNK1Dphosphorylation
up-regulates
LRP6
PThr1493
phosphorylation
up-regulates
LRP635487243SIGNOR-275403
CSNK1Dphosphorylation
up-regulates
DVL2
PThr224
phosphorylation
up-regulates
DVL222609948SIGNOR-197551
CSNK1Dphosphorylation
up-regulates
MDM2
PSer253
phosphorylation
down-regulates
MDM220708156SIGNOR-167513
CSNK1Dphosphorylation
up-regulates
PSEN2
PSer335
phosphorylation
up-regulates
PSEN29558331SIGNOR-250802
CSNK1Dphosphorylation
up-regulates
MDM2
PSer262
phosphorylation
down-regulates
MDM212167711SIGNOR-91199
CSNK1Dphosphorylation
up-regulates
PSEN2
PSer330
phosphorylation
up-regulates
PSEN29558331SIGNOR-250801
CSNK1Dphosphorylation
up-regulates
GJA1
PSer325
phosphorylation
up-regulates
GJA112270943SIGNOR-249329
CSNK1Dphosphorylation
up-regulates
MAPT
PSer721
phosphorylation
down-regulates
MAPT14761950SIGNOR-121713
CSNK1Dphosphorylation
up-regulates
MTSS1
PSer322
phosphorylation
down-regulates
MTSS124318128SIGNOR-276611
CSNK1Dphosphorylation
up-regulates
MDM2
PSer121
phosphorylation
down-regulates
MDM220708156SIGNOR-167501
CSNK1Dphosphorylation
up-regulates
TP53
PSer20
phosphorylation
up-regulates
TP5310734067SIGNOR-75889
CSNK1Dphosphorylation
up-regulates
NCOA3
PSer601
phosphorylation
up-regulates
NCOA319339517SIGNOR-184946
CSNK1Dphosphorylation
up-regulates
KIR3DL1
PSer385
phosphorylation
up-regulates
KIR3DL117911614SIGNOR-158121
CSNK1Dphosphorylation
up-regulates
TP53
PSer20
phosphorylation
up-regulates
TP5310606744SIGNOR-73266
CSNK1Dphosphorylation
up-regulates
AXIN1
PSer46
phosphorylation
up-regulates
AXIN112000790SIGNOR-87437
CSNK1Dphosphorylation
up-regulates
PSEN2
PSer19
phosphorylation
down-regulates
PSEN28972483SIGNOR-250799
CSNK1Dphosphorylation
up-regulates
GJA1
PSer328
phosphorylation
up-regulates
GJA112270943SIGNOR-249330
CSNK1Dphosphorylation
up-regulates
SMARCA4
PSer31
phosphorylation
down-regulates
SMARCA430177679SIGNOR-277408
CSNK1Dphosphorylation
up-regulates
DVL2
PSer143
phosphorylation
up-regulates
DVL222609948SIGNOR-197547
CSNK1Dphosphorylation
up-regulates
PRH1
PSer24
phosphorylation
up-regulates
PRH110684652SIGNOR-75272
CSNK1Dphosphorylation
up-regulates
MDM2
PSer269
phosphorylation
down-regulates
MDM212167711SIGNOR-91191
CSNK1Dphosphorylation
up-regulates
PPP5C
PThr362
phosphorylation
up-regulates
PPP5C29141220SIGNOR-277373
CSNK1Dphosphorylation
up-regulates
YAP1
PSer403
phosphorylation
down-regulates
YAP123431053SIGNOR-201154
CSNK1Dphosphorylation
up-regulates
UHRF1
PSer95
phosphorylation
up-regulates
UHRF123297342SIGNOR-200349
CSNK1Dphosphorylation
up-regulates
DCK
PSer74
phosphorylation
up-regulates
DCK20637175SIGNOR-275799
CSNK1Dphosphorylation
up-regulates
HIF1A
PSer247
phosphorylation
down-regulates
HIF1A20699359SIGNOR-167476
CSNK1Dphosphorylation
up-regulates
MDM2
PSer118
phosphorylation
down-regulates
MDM220708156SIGNOR-167497
CSNK1Dphosphorylation
up-regulates
MDM2
PSer262
phosphorylation
down-regulates
MDM220708156SIGNOR-167517
CSNK1Dphosphorylation
up-regulates
YAP1
PSer400
phosphorylation
down-regulates
YAP124715453SIGNOR-230738
CSNK1Dphosphorylation
up-regulates
MAPT
PSer396
phosphorylation
down-regulates
MAPT14761950SIGNOR-121709
CSNK1Dphosphorylation
up-regulates
PSEN2
PSer327
phosphorylation
up-regulates
PSEN29558331SIGNOR-250800
CSNK1Dphosphorylation
up-regulates
PSEN2
PSer7
phosphorylation
down-regulates
PSEN28972483SIGNOR-250803
CSNK1Dphosphorylation
up-regulates
SMARCA4
PSer35
phosphorylation
down-regulates
SMARCA430177679SIGNOR-277407
CSNK1Dphosphorylation
up-regulates
CDK5
PSer159
phosphorylation
up-regulates
CDK510500146SIGNOR-250798
CSNK1Dphosphorylation
up-regulates
MAPT
PThr522
phosphorylation
down-regulates
MAPT14761950SIGNOR-121717
CSNK1Dphosphorylation
up-regulates
CTNNB1
PSer45
phosphorylation
down-regulates
CTNNB112000790SIGNOR-87441
CSNK1Dphosphorylation
up-regulates
TOP2B
PSer1132
phosphorylation
down-regulates
TOP2B32015321SIGNOR-277509
CSNK1Dphosphorylation
up-regulates
LRP6
PThr1479
phosphorylation
up-regulates
LRP635487243SIGNOR-275402
CSNK1Dphosphorylation
up-regulates
MDM2
PSer246
phosphorylation
down-regulates
MDM220708156SIGNOR-167509
CSNK1Dphosphorylation
up-regulates
ZNF322
PSer396
phosphorylation
down-regulates
ZNF32228581525SIGNOR-264892
CSNK1Dphosphorylation
up-regulates
MDM2
PSer253
phosphorylation
down-regulates
MDM212167711SIGNOR-91195
Regulator Mechanism/Effect Target SIGNOR-ID
CSNK1Dphosphorylation

unknown
PSEN2SIGNOR-250804
CSNK1Dphosphorylation

unknown
BACE1SIGNOR-250797
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MAPTSIGNOR-121705
CSNK1Dphosphorylation

up-regulates activity
DCKSIGNOR-280233
CSNK1Dphosphorylation

down-regulates activity
ERGSIGNOR-280234
CSNK1Dphosphorylation

down-regulates activity
KDRSIGNOR-280235
CSNK1Dphosphorylation

up-regulates
TP53SIGNOR-73270
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
WWTR1SIGNOR-234438
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-201143
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-230743
CSNK1Dphosphorylation

down-regulates activity
CDH1SIGNOR-274046
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PER2SIGNOR-277420
CSNK1Dphosphorylation

up-regulates activity
GJA1SIGNOR-249331
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
WEE1SIGNOR-276631
CSNK1Dphosphorylation

up-regulates
KIR3DL1SIGNOR-158125
CSNK1Dphosphorylation

up-regulates activity
LRP6SIGNOR-275403
CSNK1Dphosphorylation

up-regulates
DVL2SIGNOR-197551
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PER2SIGNOR-268000
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PER1SIGNOR-268001
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MDM2SIGNOR-167513
CSNK1Dphosphorylation

up-regulates activity
MAPRE1SIGNOR-279165
CSNK1Dphosphorylation

up-regulates activity
PSEN2SIGNOR-250802
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MDM2SIGNOR-91199
CSNK1Dphosphorylation

up-regulates activity
PSEN2SIGNOR-250801
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PER3SIGNOR-267998
CSNK1Dphosphorylation

up-regulates activity
GJA1SIGNOR-249329
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MAPTSIGNOR-121713
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
MTSS1SIGNOR-276611
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MDM2SIGNOR-167501
CSNK1Dphosphorylation

up-regulates
TP53SIGNOR-75889
CSNK1Dphosphorylation

up-regulates
NCOA3SIGNOR-184946
CSNK1Dphosphorylation

up-regulates
KIR3DL1SIGNOR-158121
CSNK1Dphosphorylation

up-regulates
TP53SIGNOR-73266
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
LEF1SIGNOR-134494
CSNK1Dphosphorylation

up-regulates
AXIN1SIGNOR-87437
CSNK1Dphosphorylation

unknown
PSEN2SIGNOR-250799
CSNK1Dphosphorylation

up-regulates activity
GJA1SIGNOR-249330
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
SMARCA4SIGNOR-277408
CSNK1Dphosphorylation

up-regulates
DVL2SIGNOR-197547
CSNK1Dphosphorylation

up-regulates
PRH1SIGNOR-75272
CSNK1Dphosphorylation

down-regulates activity
MDM2SIGNOR-91191
CSNK1Dphosphorylation

up-regulates activity
PPP5CSIGNOR-277373
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-201154
CSNK1Dphosphorylation

up-regulates
UHRF1SIGNOR-200349
CSNK1Dphosphorylation

up-regulates
GSK3B/Axin/APCSIGNOR-227970
CSNK1Dphosphorylation

up-regulates activity
DCKSIGNOR-275799
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
HIF1ASIGNOR-167476
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MDM2SIGNOR-167497
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PER1SIGNOR-267999
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MDM2SIGNOR-167517
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-230738
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MDM2SIGNOR-167520
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MAPTSIGNOR-121709
CSNK1Dphosphorylation

up-regulates activity
PSEN2SIGNOR-250800
CSNK1Dphosphorylation

unknown
PSEN2SIGNOR-250803
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
SMARCA4SIGNOR-277407
CSNK1Dphosphorylation

up-regulates activity
CDK5SIGNOR-250798
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MAPTSIGNOR-121717
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
CTNNB1SIGNOR-87441
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
TOP2BSIGNOR-277509
CSNK1Dphosphorylation

up-regulates activity
LRP6SIGNOR-275402
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MDM2SIGNOR-167509
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
ZNF322SIGNOR-264892
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
MDM2SIGNOR-91195