Entity Details

Name PIK3CG
ID P48736
Role kinase
Enzymatic Domains
PI3K-ABD 34-141
PROSITE-ProRule
PI3K-RBD 217-309
PROSITE-ProRule
C2 PI3K-type 357-521
PROSITE-ProRule
PIK helical 541-723
PROSITE-ProRule
PI3K/PI4K catalytic 797-1080
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PIK3CGTPM2Ser61EDEVEKYsESVKEAQphosphorylation
up-regulates activity		16094730SIGNOR-263028
PIK3CGSRCSer39FPASQTPsKPASADGphosphorylation
up-regulates activity		27169346SIGNOR-279748
PIK3CGSRCSer70LFGGFNSsDTVTSPQphosphorylation
up-regulates activity		27169346SIGNOR-277225
PIK3CGSET–phosphorylation
up-regulates activity		21419339SIGNOR-278320
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PIK3CGphosphorylation
up-regulates
→
TPM2
PSer61		phosphorylation
up-regulates
→		TPM216094730SIGNOR-263028
PIK3CGphosphorylation
up-regulates
→
SRC
PSer39		phosphorylation
up-regulates
→		SRC27169346SIGNOR-279748
PIK3CGphosphorylation
up-regulates
→
SRC
PSer70		phosphorylation
up-regulates
→		SRC27169346SIGNOR-277225
Regulator Mechanism/Effect Target SIGNOR-ID
PIK3CGphosphorylation
→
up-regulates activity 		TPM2SIGNOR-263028
PIK3CGphosphorylation
→
up-regulates activity 		SRCSIGNOR-279748
PIK3CGphosphorylation
→
up-regulates activity 		SRCSIGNOR-277225
PIK3CGphosphorylation
→
up-regulates activity 		SETSIGNOR-278320