| Name | PIK3CG |
| ID | P48736 |
| Role | substrate |
| Enzymatic Domains |
PI3K-ABD 34-141 PROSITE-ProRule
PI3K-RBD 217-309 PROSITE-ProRule
C2 PI3K-type 357-521 PROSITE-ProRule
PIK helical 541-723 PROSITE-ProRule
PI3K/PI4K catalytic 797-1080 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | PIK3CG | Thr1024 | YLALRHHtNLLIILF | phosphorylation down-regulates activity | 21474070 | SIGNOR-276321 |
| PRKCB | PIK3CG | Ser582 | LWHFRYEsLKHPKAY | phosphorylation up-regulates activity | 23824069 | SIGNOR-276496 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | PIK3CG PThr1024 | phosphorylation down-regulates ⊣ | PIK3CG | 21474070 | SIGNOR-276321 |
| PRKCB | phosphorylation up-regulates → | PIK3CG PSer582 | phosphorylation up-regulates → | PIK3CG | 23824069 | SIGNOR-276496 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | PIK3CG | SIGNOR-276321 |
| PRKCB | phosphorylation → up-regulates activity | PIK3CG | SIGNOR-276496 |