| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG2 | SLC9A3 | – | phosphorylation down-regulates activity | 25480791 | SIGNOR-280096 | |
| PKA | SLC9A3 | Ser555 | AEGERRGsLAFIRSP | phosphorylation down-regulates activity | 38047302 | SIGNOR-277847 |
| AMPK | SLC9A3 | Ser563 | LAFIRSPsTDNVVNV | phosphorylation down-regulates activity | 38047302 | SIGNOR-277848 |
| SGK1 | SLC9A3 | Ser663 | TMRKRLEsFKSTKLG | phosphorylation up-regulates activity | 21054167 | SIGNOR-279112 |
| AMPK | SLC9A3 | Ser555 | AEGERRGsLAFIRSP | phosphorylation down-regulates activity | 38047302 | SIGNOR-277849 |
| MAST2 | SLC9A3 | – | phosphorylation down-regulates activity | 16159897 | SIGNOR-279229 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | SLC9A3 PSer555 | phosphorylation down-regulates ⊣ | SLC9A3 | 38047302 | SIGNOR-277847 |
| AMPK | phosphorylation up-regulates → | SLC9A3 PSer563 | phosphorylation down-regulates ⊣ | SLC9A3 | 38047302 | SIGNOR-277848 |
| SGK1 | phosphorylation up-regulates → | SLC9A3 PSer663 | phosphorylation up-regulates → | SLC9A3 | 21054167 | SIGNOR-279112 |
| AMPK | phosphorylation up-regulates → | SLC9A3 PSer555 | phosphorylation down-regulates ⊣ | SLC9A3 | 38047302 | SIGNOR-277849 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKG2 | phosphorylation → down-regulates activity | SLC9A3 | SIGNOR-280096 |
| PKA | phosphorylation → down-regulates activity | SLC9A3 | SIGNOR-277847 |
| AMPK | phosphorylation → down-regulates activity | SLC9A3 | SIGNOR-277848 |
| SGK1 | phosphorylation → up-regulates activity | SLC9A3 | SIGNOR-279112 |
| AMPK | phosphorylation → down-regulates activity | SLC9A3 | SIGNOR-277849 |
| MAST2 | phosphorylation → down-regulates activity | SLC9A3 | SIGNOR-279229 |
