Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTPRT	PXN	Tyr88 View in OncoXplorer	PQSSSPVyGSSAKTS	dephosphorylation down-regulates activity	27447856	SIGNOR-263978
PAK1	PXN	Ser272 View in OncoXplorer	ELDELMAsLSDFKIQ	phosphorylation unknown	16717130	SIGNOR-146842
PTK2B	PXN	–		phosphorylation down-regulates quantity by destabilization	15263022	SIGNOR-279272
MAPK8	PXN	Ser178 View in OncoXplorer	PPLPGALsPLYGVPE	phosphorylation up-regulates activity	12853963	SIGNOR-250129
PTPRG	PXN	Tyr118 View in OncoXplorer	VGEEEHVySFPNKQK	dephosphorylation up-regulates activity	25624455	SIGNOR-254721
PTK2	PXN	Tyr118 View in OncoXplorer	VGEEEHVySFPNKQK	phosphorylation up-regulates activity	15688067	SIGNOR-28243
PTPRR	PXN	Tyr88 View in OncoXplorer	PQSSSPVyGSSAKTS	dephosphorylation down-regulates activity	20133777	SIGNOR-248720
MAPK14	PXN	Ser85 View in OncoXplorer	HQQPQSSsPVYGSSA	phosphorylation unknown	14970194	SIGNOR-122108
PAK4	PXN	Ser272 View in OncoXplorer	ELDELMAsLSDFKIQ	phosphorylation unknown	20406887	SIGNOR-164889
SRC	PXN	Tyr88 View in OncoXplorer	PQSSSPVyGSSAKTS	phosphorylation up-regulates activity	27447856	SIGNOR-263977
PTK2	PXN	Tyr31	FLSEETPySYPTGNH	phosphorylation up-regulates activity	15688067	SIGNOR-28247
CDK5	PXN	Ser85 View in OncoXplorer	HQQPQSSsPVYGSSA	phosphorylation up-regulates activity	14970194	SIGNOR-278921
PTPRG	PXN	–		dephosphorylation up-regulates activity	25624455	SIGNOR-254722
MAP3K2	PXN	–		phosphorylation down-regulates quantity	25190348	SIGNOR-278955
PTK6	PXN	–		phosphorylation up-regulates activity	33391524	SIGNOR-280102

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTPRT	dephosphorylation down-regulates ⊣	PXN PTyr88	dephosphorylation up-regulates →	PXN	27447856	SIGNOR-263978
PAK1	phosphorylation up-regulates →	PXN PSer272	phosphorylation down-regulates ⊣	PXN	16717130	SIGNOR-146842
MAPK8	phosphorylation up-regulates →	PXN PSer178	phosphorylation up-regulates →	PXN	12853963	SIGNOR-250129
PTPRG	dephosphorylation down-regulates ⊣	PXN PTyr118	dephosphorylation down-regulates ⊣	PXN	25624455	SIGNOR-254721
PTK2	phosphorylation up-regulates →	PXN PTyr118	phosphorylation up-regulates →	PXN	15688067	SIGNOR-28243
PTPRR	dephosphorylation down-regulates ⊣	PXN PTyr88	dephosphorylation up-regulates →	PXN	20133777	SIGNOR-248720
MAPK14	phosphorylation up-regulates →	PXN PSer85	phosphorylation down-regulates ⊣	PXN	14970194	SIGNOR-122108
PAK4	phosphorylation up-regulates →	PXN PSer272	phosphorylation down-regulates ⊣	PXN	20406887	SIGNOR-164889
SRC	phosphorylation up-regulates →	PXN PTyr88	phosphorylation up-regulates →	PXN	27447856	SIGNOR-263977
PTK2	phosphorylation up-regulates →	PXN PTyr31	phosphorylation up-regulates →	PXN	15688067	SIGNOR-28247
CDK5	phosphorylation up-regulates →	PXN PSer85	phosphorylation up-regulates →	PXN	14970194	SIGNOR-278921

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTPRT	dephosphorylation → down-regulates activity	PXN	SIGNOR-263978
PAK1	phosphorylation → unknown	PXN	SIGNOR-146842
PTK2B	phosphorylation down-regulates quantity by destabilization	PXN	SIGNOR-279272
MAPK8	phosphorylation → up-regulates activity	PXN	SIGNOR-250129
PTPRG	dephosphorylation → up-regulates activity	PXN	SIGNOR-254721
PTK2	phosphorylation → up-regulates activity	PXN	SIGNOR-28243
PTPRR	dephosphorylation → down-regulates activity	PXN	SIGNOR-248720
MAPK14	phosphorylation → unknown	PXN	SIGNOR-122108
PAK4	phosphorylation → unknown	PXN	SIGNOR-164889
SRC	phosphorylation → up-regulates activity	PXN	SIGNOR-263977
PTK2	phosphorylation → up-regulates activity	PXN	SIGNOR-28247
CDK5	phosphorylation → up-regulates activity	PXN	SIGNOR-278921
PTPRG	dephosphorylation → up-regulates activity	PXN	SIGNOR-254722
MAP3K2	phosphorylation → down-regulates quantity	PXN	SIGNOR-278955
PTK6	phosphorylation → up-regulates activity	PXN	SIGNOR-280102