| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | PXN | Tyr118 | VGEEEHVySFPNKQK | phosphorylation up-regulates activity | 15688067 | SIGNOR-28243 |
| PTPRG | PXN | Tyr118 | VGEEEHVySFPNKQK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254721 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | phosphorylation up-regulates → | PXN PTyr118 | phosphorylation up-regulates → | PXN | 15688067 | SIGNOR-28243 |
| PTPRG | dephosphorylation down-regulates ⊣ | PXN PTyr118 | dephosphorylation down-regulates ⊣ | PXN | 25624455 | SIGNOR-254721 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2 | phosphorylation → up-regulates activity | PXN | SIGNOR-28243 |
| PTPRG | dephosphorylation → up-regulates activity | PXN | SIGNOR-254721 |
