| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRR | PXN | Tyr88 | PQSSSPVyGSSAKTS | dephosphorylation down-regulates activity | 20133777 | SIGNOR-248720 |
| PTPRT | PXN | Tyr88 | PQSSSPVyGSSAKTS | dephosphorylation down-regulates activity | 27447856 | SIGNOR-263978 |
| SRC | PXN | Tyr88 | PQSSSPVyGSSAKTS | phosphorylation up-regulates activity | 27447856 | SIGNOR-263977 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRR | dephosphorylation down-regulates ⊣ | PXN PTyr88 | dephosphorylation up-regulates → | PXN | 20133777 | SIGNOR-248720 |
| PTPRT | dephosphorylation down-regulates ⊣ | PXN PTyr88 | dephosphorylation up-regulates → | PXN | 27447856 | SIGNOR-263978 |
| SRC | phosphorylation up-regulates → | PXN PTyr88 | phosphorylation up-regulates → | PXN | 27447856 | SIGNOR-263977 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRR | dephosphorylation → down-regulates activity | PXN | SIGNOR-248720 |
| PTPRT | dephosphorylation → down-regulates activity | PXN | SIGNOR-263978 |
| SRC | phosphorylation → up-regulates activity | PXN | SIGNOR-263977 |
