| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | DHPS | Ser233 | KNHIPVFsPALTDGS | phosphorylation up-regulates activity | 32989218 | SIGNOR-266376 |
| ERK1/2 | DHPS | Ser233 | KNHIPVFsPALTDGS | phosphorylation up-regulates activity | 32989218 | SIGNOR-277822 |
| ERK1/2 | DHPS | Ser233 | KNHIPVFsPALTDGS | phosphorylation up-regulates activity | 32989218 | SIGNOR-277815 |
| ERK1/2 | DHPS | Ser233 | KNHIPVFsPALTDGS | phosphorylation up-regulates activity | 32989218 | SIGNOR-277801 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | DHPS PSer233 | phosphorylation up-regulates → | DHPS | 32989218 | SIGNOR-266376 |
| ERK1/2 | phosphorylation up-regulates → | DHPS PSer233 | phosphorylation up-regulates → | DHPS | 32989218 | SIGNOR-277822 |
| ERK1/2 | phosphorylation up-regulates → | DHPS PSer233 | phosphorylation up-regulates → | DHPS | 32989218 | SIGNOR-277815 |
| ERK1/2 | phosphorylation up-regulates → | DHPS PSer233 | phosphorylation up-regulates → | DHPS | 32989218 | SIGNOR-277801 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation → up-regulates activity | DHPS | SIGNOR-266376 |
| ERK1/2 | phosphorylation → up-regulates activity | DHPS | SIGNOR-277822 |
| ERK1/2 | phosphorylation → up-regulates activity | DHPS | SIGNOR-277815 |
| ERK1/2 | phosphorylation → up-regulates activity | DHPS | SIGNOR-277801 |
