| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | ARRB1 | Ser163 | EKIHKRNsVRLVIRK | phosphorylation up-regulates activity | 24502978 | SIGNOR-276619 |
| MAPK3 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 15456867 | SIGNOR-129589 |
| ERK1/2 | ARRB1 | – | phosphorylation down-regulates | 10347142 | SIGNOR-270190 | |
| MAPK1 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 10347142 | SIGNOR-67630 |
| SRC | ARRB1 | Tyr54 | YLKERRVyVTLTCAF | phosphorylation down-regulates | 17456551 | SIGNOR-154564 |
| Gbeta | ARRB1 | – | phosphorylation down-regulates | 10347142 | SIGNOR-270094 | |
| MAPK1 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 19153083 | SIGNOR-183480 |
| MAPK1 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 15456867 | SIGNOR-129585 |
| MAPK3 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 19153083 | SIGNOR-183484 |
| MAPK3 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 10347142 | SIGNOR-67634 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | ARRB1 PSer163 | phosphorylation up-regulates → | ARRB1 | 24502978 | SIGNOR-276619 |
| MAPK3 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 15456867 | SIGNOR-129589 |
| MAPK1 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 10347142 | SIGNOR-67630 |
| SRC | phosphorylation up-regulates → | ARRB1 PTyr54 | phosphorylation down-regulates ⊣ | ARRB1 | 17456551 | SIGNOR-154564 |
| MAPK1 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 19153083 | SIGNOR-183480 |
| MAPK1 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 15456867 | SIGNOR-129585 |
| MAPK3 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 19153083 | SIGNOR-183484 |
| MAPK3 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 10347142 | SIGNOR-67634 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → up-regulates activity | ARRB1 | SIGNOR-276619 |
| MAPK3 | phosphorylation down-regulates | ARRB1 | SIGNOR-129589 |
| ERK1/2 | phosphorylation down-regulates | ARRB1 | SIGNOR-270190 |
| MAPK1 | phosphorylation down-regulates | ARRB1 | SIGNOR-67630 |
| SRC | phosphorylation down-regulates | ARRB1 | SIGNOR-154564 |
| Gbeta | phosphorylation down-regulates | ARRB1 | SIGNOR-270094 |
| MAPK1 | phosphorylation down-regulates | ARRB1 | SIGNOR-183480 |
| MAPK1 | phosphorylation down-regulates | ARRB1 | SIGNOR-129585 |
| MAPK3 | phosphorylation down-regulates | ARRB1 | SIGNOR-183484 |
| MAPK3 | phosphorylation down-regulates | ARRB1 | SIGNOR-67634 |
