| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 15456867 | SIGNOR-129589 |
| MAPK1 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 10347142 | SIGNOR-67630 |
| MAPK1 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 19153083 | SIGNOR-183480 |
| MAPK1 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 15456867 | SIGNOR-129585 |
| MAPK3 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 19153083 | SIGNOR-183484 |
| MAPK3 | ARRB1 | Ser412 | EEEDGTGsPQLNNR | phosphorylation down-regulates | 10347142 | SIGNOR-67634 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 15456867 | SIGNOR-129589 |
| MAPK1 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 10347142 | SIGNOR-67630 |
| MAPK1 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 19153083 | SIGNOR-183480 |
| MAPK1 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 15456867 | SIGNOR-129585 |
| MAPK3 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 19153083 | SIGNOR-183484 |
| MAPK3 | phosphorylation up-regulates → | ARRB1 PSer412 | phosphorylation down-regulates ⊣ | ARRB1 | 10347142 | SIGNOR-67634 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates | ARRB1 | SIGNOR-129589 |
| MAPK1 | phosphorylation down-regulates | ARRB1 | SIGNOR-67630 |
| MAPK1 | phosphorylation down-regulates | ARRB1 | SIGNOR-183480 |
| MAPK1 | phosphorylation down-regulates | ARRB1 | SIGNOR-129585 |
| MAPK3 | phosphorylation down-regulates | ARRB1 | SIGNOR-183484 |
| MAPK3 | phosphorylation down-regulates | ARRB1 | SIGNOR-67634 |
