Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK5	AMPH	Ser285	NHTLAPAsPAPARPR	phosphorylation unknown	11113134	SIGNOR-250650
CDKL5	AMPH	Ser293	PAPARPRsPSQTRKG	phosphorylation down-regulates activity	23651931	SIGNOR-245881
DYRK1A	AMPH	Ser262	LRIAKTPsPPEEPSP	phosphorylation down-regulates	15262992	SIGNOR-126839
CSNK2A1	AMPH	Thr387	LPWDLWTtSTDLVQP	phosphorylation down-regulates	16945112	SIGNOR-149318
CDK5	AMPH	Ser276 View in OncoXplorer	PLPSPTAsPNHTLAP	phosphorylation unknown	11113134	SIGNOR-250649
DYRK1A	AMPH	Ser295	PARPRSPsQTRKGPP	phosphorylation down-regulates	16733250	SIGNOR-146906
CyclinB/CDK1	AMPH	Ser285	NHTLAPAsPAPARPR	phosphorylation unknown	11113134	SIGNOR-250646
DYRK1A	AMPH	Thr310 View in OncoXplorer	VPPLPKVtPTKELQQ	phosphorylation down-regulates	16733250	SIGNOR-146910
MAPK1	AMPH	Ser295	PARPRSPsQTRKGPP	phosphorylation down-regulates	15262992	SIGNOR-126863
CyclinB/CDK1	AMPH	Ser272 View in OncoXplorer	EEPSPLPsPTASPNH	phosphorylation unknown	11113134	SIGNOR-250644
DYRK1A	AMPH	Ser276 View in OncoXplorer	PLPSPTAsPNHTLAP	phosphorylation down-regulates	15262992	SIGNOR-126847
DYRK1A	AMPH	Ser293	PAPARPRsPSQTRKG	phosphorylation down-regulates activity	16733250	SIGNOR-146902
ERK1/2	AMPH	–		phosphorylation down-regulates	15262992	SIGNOR-270197
CDK5	AMPH	Ser272 View in OncoXplorer	EEPSPLPsPTASPNH	phosphorylation unknown	11113134	SIGNOR-250648
MAPK3	AMPH	Ser293	PAPARPRsPSQTRKG	phosphorylation down-regulates activity	15262992	SIGNOR-126867
MAPK1	AMPH	Ser293	PAPARPRsPSQTRKG	phosphorylation down-regulates activity	15262992	SIGNOR-126859
MAPK3	AMPH	Ser295	PARPRSPsQTRKGPP	phosphorylation down-regulates	15262992	SIGNOR-126871
Gbeta	AMPH	–		phosphorylation down-regulates	15262992	SIGNOR-270102
DYRK1A	AMPH	Ser285	NHTLAPAsPAPARPR	phosphorylation down-regulates	15262992	SIGNOR-126851
DYRK1A	AMPH	Thr310 View in OncoXplorer	VPPLPKVtPTKELQQ	phosphorylation down-regulates	15262992	SIGNOR-126855
CyclinB/CDK1	AMPH	Ser276 View in OncoXplorer	PLPSPTAsPNHTLAP	phosphorylation unknown	11113134	SIGNOR-250645
CSNK2A1	AMPH	Thr350	PEVKKEEtLLDLDFD	phosphorylation down-regulates	16945112	SIGNOR-149314
DYRK1A	AMPH	Ser272 View in OncoXplorer	EEPSPLPsPTASPNH	phosphorylation down-regulates	15262992	SIGNOR-126843

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK5	phosphorylation up-regulates →	AMPH PSer285	phosphorylation down-regulates ⊣	AMPH	11113134	SIGNOR-250650
CDKL5	phosphorylation up-regulates →	AMPH PSer293	phosphorylation down-regulates ⊣	AMPH	23651931	SIGNOR-245881
DYRK1A	phosphorylation up-regulates →	AMPH PSer262	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126839
CSNK2A1	phosphorylation up-regulates →	AMPH PThr387	phosphorylation down-regulates ⊣	AMPH	16945112	SIGNOR-149318
CDK5	phosphorylation up-regulates →	AMPH PSer276	phosphorylation down-regulates ⊣	AMPH	11113134	SIGNOR-250649
DYRK1A	phosphorylation up-regulates →	AMPH PSer295	phosphorylation down-regulates ⊣	AMPH	16733250	SIGNOR-146906
CyclinB/CDK1	phosphorylation up-regulates →	AMPH PSer285	phosphorylation down-regulates ⊣	AMPH	11113134	SIGNOR-250646
DYRK1A	phosphorylation up-regulates →	AMPH PThr310	phosphorylation down-regulates ⊣	AMPH	16733250	SIGNOR-146910
MAPK1	phosphorylation up-regulates →	AMPH PSer295	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126863
CyclinB/CDK1	phosphorylation up-regulates →	AMPH PSer272	phosphorylation down-regulates ⊣	AMPH	11113134	SIGNOR-250644
DYRK1A	phosphorylation up-regulates →	AMPH PSer276	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126847
DYRK1A	phosphorylation up-regulates →	AMPH PSer293	phosphorylation down-regulates ⊣	AMPH	16733250	SIGNOR-146902
CDK5	phosphorylation up-regulates →	AMPH PSer272	phosphorylation down-regulates ⊣	AMPH	11113134	SIGNOR-250648
MAPK3	phosphorylation up-regulates →	AMPH PSer293	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126867
MAPK1	phosphorylation up-regulates →	AMPH PSer293	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126859
MAPK3	phosphorylation up-regulates →	AMPH PSer295	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126871
DYRK1A	phosphorylation up-regulates →	AMPH PSer285	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126851
DYRK1A	phosphorylation up-regulates →	AMPH PThr310	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126855
CyclinB/CDK1	phosphorylation up-regulates →	AMPH PSer276	phosphorylation down-regulates ⊣	AMPH	11113134	SIGNOR-250645
CSNK2A1	phosphorylation up-regulates →	AMPH PThr350	phosphorylation down-regulates ⊣	AMPH	16945112	SIGNOR-149314
DYRK1A	phosphorylation up-regulates →	AMPH PSer272	phosphorylation down-regulates ⊣	AMPH	15262992	SIGNOR-126843

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK5	phosphorylation → unknown	AMPH	SIGNOR-250650
CDKL5	phosphorylation → down-regulates activity	AMPH	SIGNOR-245881
DYRK1A	phosphorylation down-regulates	AMPH	SIGNOR-126839
CSNK2A1	phosphorylation down-regulates	AMPH	SIGNOR-149318
CDK5	phosphorylation → unknown	AMPH	SIGNOR-250649
DYRK1A	phosphorylation down-regulates	AMPH	SIGNOR-146906
CyclinB/CDK1	phosphorylation → unknown	AMPH	SIGNOR-250646
DYRK1A	phosphorylation down-regulates	AMPH	SIGNOR-146910
MAPK1	phosphorylation down-regulates	AMPH	SIGNOR-126863
CyclinB/CDK1	phosphorylation → unknown	AMPH	SIGNOR-250644
DYRK1A	phosphorylation down-regulates	AMPH	SIGNOR-126847
DYRK1A	phosphorylation → down-regulates activity	AMPH	SIGNOR-146902
ERK1/2	phosphorylation down-regulates	AMPH	SIGNOR-270197
CDK5	phosphorylation → unknown	AMPH	SIGNOR-250648
MAPK3	phosphorylation → down-regulates activity	AMPH	SIGNOR-126867
MAPK1	phosphorylation → down-regulates activity	AMPH	SIGNOR-126859
MAPK3	phosphorylation down-regulates	AMPH	SIGNOR-126871
Gbeta	phosphorylation down-regulates	AMPH	SIGNOR-270102
DYRK1A	phosphorylation down-regulates	AMPH	SIGNOR-126851
DYRK1A	phosphorylation down-regulates	AMPH	SIGNOR-126855
CyclinB/CDK1	phosphorylation → unknown	AMPH	SIGNOR-250645
CSNK2A1	phosphorylation down-regulates	AMPH	SIGNOR-149314
DYRK1A	phosphorylation down-regulates	AMPH	SIGNOR-126843