| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | AMPH | Ser285 | NHTLAPAsPAPARPR | phosphorylation down-regulates | 15262992 | SIGNOR-126851 |
| CDK5 | AMPH | Ser285 | NHTLAPAsPAPARPR | phosphorylation unknown | 11113134 | SIGNOR-250650 |
| CyclinB/CDK1 | AMPH | Ser285 | NHTLAPAsPAPARPR | phosphorylation unknown | 11113134 | SIGNOR-250646 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | AMPH PSer285 | phosphorylation down-regulates ⊣ | AMPH | 15262992 | SIGNOR-126851 |
| CDK5 | phosphorylation up-regulates → | AMPH PSer285 | phosphorylation down-regulates ⊣ | AMPH | 11113134 | SIGNOR-250650 |
| CyclinB/CDK1 | phosphorylation up-regulates → | AMPH PSer285 | phosphorylation down-regulates ⊣ | AMPH | 11113134 | SIGNOR-250646 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation down-regulates | AMPH | SIGNOR-126851 |
| CDK5 | phosphorylation → unknown | AMPH | SIGNOR-250650 |
| CyclinB/CDK1 | phosphorylation → unknown | AMPH | SIGNOR-250646 |
