| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | AMPH | Ser295 | PARPRSPsQTRKGPP | phosphorylation down-regulates | 16733250 | SIGNOR-146906 |
| MAPK1 | AMPH | Ser295 | PARPRSPsQTRKGPP | phosphorylation down-regulates | 15262992 | SIGNOR-126863 |
| MAPK3 | AMPH | Ser295 | PARPRSPsQTRKGPP | phosphorylation down-regulates | 15262992 | SIGNOR-126871 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | AMPH PSer295 | phosphorylation down-regulates ⊣ | AMPH | 16733250 | SIGNOR-146906 |
| MAPK1 | phosphorylation up-regulates → | AMPH PSer295 | phosphorylation down-regulates ⊣ | AMPH | 15262992 | SIGNOR-126863 |
| MAPK3 | phosphorylation up-regulates → | AMPH PSer295 | phosphorylation down-regulates ⊣ | AMPH | 15262992 | SIGNOR-126871 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation down-regulates | AMPH | SIGNOR-146906 |
| MAPK1 | phosphorylation down-regulates | AMPH | SIGNOR-126863 |
| MAPK3 | phosphorylation down-regulates | AMPH | SIGNOR-126871 |
