| Name | PPM1F |
| ID | P49593 |
| Role | phosphatase |
| Enzymatic Domains |
PPM-type phosphatase 156-413 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1F | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 31944151 | SIGNOR-276987 |
| PPM1F | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 31944151 | SIGNOR-276988 |
| PPM1F | MAP3K7 | – | dephosphorylation down-regulates activity | 28906490 | SIGNOR-277047 | |
| PPM1F | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | dephosphorylation down-regulates activity | 30863499 | SIGNOR-276989 |
| PPM1F | PAK1 | – | dephosphorylation down-regulates | 20016286 | SIGNOR-162146 | |
| PPM1F | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 11864573 | SIGNOR-248530 |
| PPM1F | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 11864573 | SIGNOR-248531 |
| PPM1F | PAK2 | – | dephosphorylation down-regulates | 20016286 | SIGNOR-162149 | |
| PPM1F | CAMK1 | – | dephosphorylation down-regulates activity | 11726284 | SIGNOR-277111 | |
| PPM1F | CAMK4 | – | dephosphorylation down-regulates activity | 11726284 | SIGNOR-277157 | |
| PPM1F | CAMK2A | Thr286 | SCMHRQEtVDCLKKF | dephosphorylation down-regulates | 15140879 | SIGNOR-124309 |
| PPM1F | PAK | – | dephosphorylation down-regulates | 20016286 | SIGNOR-269882 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1F | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 31944151 | SIGNOR-276987 |
| PPM1F | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 31944151 | SIGNOR-276988 |
| PPM1F | dephosphorylation down-regulates ⊣ | LATS1 PThr1079 | dephosphorylation up-regulates → | LATS1 | 30863499 | SIGNOR-276989 |
| PPM1F | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 11864573 | SIGNOR-248530 |
| PPM1F | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 11864573 | SIGNOR-248531 |
| PPM1F | dephosphorylation down-regulates ⊣ | CAMK2A PThr286 | dephosphorylation up-regulates → | CAMK2A | 15140879 | SIGNOR-124309 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1F | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276987 |
| PPM1F | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276988 |
| PPM1F | dephosphorylation → down-regulates activity | MAP3K7 | SIGNOR-277047 |
| PPM1F | dephosphorylation → down-regulates activity | LATS1 | SIGNOR-276989 |
| PPM1F | dephosphorylation down-regulates | PAK1 | SIGNOR-162146 |
| PPM1F | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248530 |
| PPM1F | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248531 |
| PPM1F | dephosphorylation down-regulates | PAK2 | SIGNOR-162149 |
| PPM1F | dephosphorylation → down-regulates activity | CAMK1 | SIGNOR-277111 |
| PPM1F | dephosphorylation → down-regulates activity | CAMK4 | SIGNOR-277157 |
| PPM1F | dephosphorylation down-regulates | CAMK2A | SIGNOR-124309 |
| PPM1F | dephosphorylation down-regulates | PAK | SIGNOR-269882 |