| Name | CSNK1E |
| ID | P49674 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 9-277 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | LRP6 | Ser1430 | LGYVPHPsSLSGSLP | phosphorylation up-regulates | 16513652 | SIGNOR-145053 |
| CSNK1E | YAP1 | Ser403 | ESTDSGLsMSSYSVP | phosphorylation down-regulates | 23431053 | SIGNOR-201170 |
| CSNK1E | TRAF3 | Tyr116 | EILALQIyCRNESRG | phosphorylation up-regulates activity | 32779804 | SIGNOR-277525 |
| CSNK1E | DVL2 | Thr224 | MSRFSSStEQSSASR | phosphorylation up-regulates | 22609948 | SIGNOR-197555 |
| CSNK1E | CSNK1E | Thr334 | ALPPGPPtGATANRL | phosphorylation down-regulates activity | 10542239 | SIGNOR-250812 |
| CSNK1E | DVL3 | Ser311 | EINFENMsNDDAVRV | phosphorylation down-regulates activity | 24993822 | SIGNOR-276647 |
| CSNK1E | LRP6 | Ser1420 | YVVHGPAsVPLGYVP | phosphorylation up-regulates | 16513652 | SIGNOR-145049 |
| CSNK1E | PER3 | Ser628 | LSLGSGIsQCGYSST | phosphorylation down-regulates activity | 11865049 | SIGNOR-250817 |
| CSNK1E | CSNK1E | Ser323 | RMGQLRGsATRALPP | phosphorylation down-regulates activity | 10542239 | SIGNOR-250807 |
| CSNK1E | EIF4EBP1 | Thr50 | FSTTPGGtRIIYDRK | phosphorylation down-regulates | 24247720 | SIGNOR-203276 |
| CSNK1E | PER3 | Ser625 | TAMLSLGsGISQCGY | phosphorylation down-regulates activity | 11865049 | SIGNOR-250816 |
| CSNK1E | EIF4EBP1 | Thr41 | YSTTPGGtLFSTTPG | phosphorylation down-regulates | 24247720 | SIGNOR-203240 |
| CSNK1E | CSNK1E | Thr337 | PGPPTGAtANRLRSA | phosphorylation down-regulates activity | 10542239 | SIGNOR-250813 |
| CSNK1E | LEF1 | – | phosphorylation down-regulates | 15747065 | SIGNOR-134497 | |
| CSNK1E | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates activity | 12176352 | SIGNOR-244102 |
| CSNK1E | CSNK1E | Thr407 | SRIPASQtSVPFDHL | phosphorylation down-regulates activity | 10542239 | SIGNOR-250814 |
| CSNK1E | CSNK1E | Thr325 | GQLRGSAtRALPPGP | phosphorylation down-regulates activity | 10542239 | SIGNOR-250811 |
| CSNK1E | APC | Ser1279 | SRCSSLSsLSSAEDE | phosphorylation up-regulates activity | 11487578 | SIGNOR-109660 |
| CSNK1E | GSK3B/Axin/APC | – | phosphorylation up-regulates | 12000790 | SIGNOR-227976 | |
| CSNK1E | DVL1 | Ser139 | DNETGTEsMVSHRRE | phosphorylation up-regulates activity | 16965538 | SIGNOR-217845 |
| CSNK1E | DVL3 | Ser280 | DGGIYIGsIMKGGAV | phosphorylation down-regulates activity | 24993822 | SIGNOR-276645 |
| CSNK1E | PER3 | Ser634 | ISQCGYSsTIVHVPP | phosphorylation down-regulates activity | 11865049 | SIGNOR-250819 |
| CSNK1E | TRAF3 | Tyr446 | SLYSQPFyTGYFGYK | phosphorylation up-regulates activity | 32779804 | SIGNOR-277524 |
| CSNK1E | PPP1R1B | – | phosphorylation up-regulates activity | 18991847 | SIGNOR-279701 | |
| CSNK1E | CDH1 | Ser844 | GSGSEAAsLSSLNSS | phosphorylation down-regulates activity | 17353278 | SIGNOR-274047 |
| CSNK1E | ROR2 | – | phosphorylation up-regulates | 15375164 | SIGNOR-129117 | |
| CSNK1E | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 12000790 | SIGNOR-87448 |
| CSNK1E | DVL1 | Ser142 | TGTESMVsHRRERAR | phosphorylation up-regulates activity | 16965538 | SIGNOR-217849 |
| CSNK1E | PER3 | Thr635 | SQCGYSStIVHVPPP | phosphorylation down-regulates activity | 11865049 | SIGNOR-250820 |
| CSNK1E | DVL2 | Ser143 | FHPNVSSsHENLEPE | phosphorylation up-regulates | 22609948 | SIGNOR-197063 |
| CSNK1E | AXIN1 | – | phosphorylation up-regulates | 12000790 | SIGNOR-87444 | |
| CSNK1E | PER3 | Ser633 | GISQCGYsSTIVHVP | phosphorylation down-regulates activity | 11865049 | SIGNOR-250818 |
| CSNK1E | CSNK1E | Ser405 | EVSRIPAsQTSVPFD | phosphorylation down-regulates activity | 10542239 | SIGNOR-250809 |
| CSNK1E | PER2 | – | phosphorylation down-regulates quantity by destabilization | 15767683 | SIGNOR-267995 | |
| CSNK1E | YAP1 | Ser400 | SRDESTDsGLSMSSY | phosphorylation down-regulates | 23431053 | SIGNOR-201165 |
| CSNK1E | DVL2 | – | phosphorylation up-regulates activity | 10517632 | SIGNOR-244097 | |
| CSNK1E | YAP1 | Ser400 | SRDESTDsGLSMSSY | phosphorylation down-regulates | 24715453 | SIGNOR-230728 |
| CSNK1E | CSNK1E | Ser368 | NTSPRAIsRVDRERK | phosphorylation down-regulates activity | 10542239 | SIGNOR-250808 |
| CSNK1E | CSNK1E | Ser408 | RIPASQTsVPFDHLG | phosphorylation down-regulates activity | 10542239 | SIGNOR-250810 |
| CSNK1E | APC | Ser1392 | SRCTSVSsLDSFESR | phosphorylation up-regulates activity | 11487578 | SIGNOR-109664 |
| CSNK1E | TCF3 | – | phosphorylation up-regulates | 11524435 | SIGNOR-110056 | |
| CSNK1E | YAP1 | Ser403 | ESTDSGLsMSSYSVP | phosphorylation down-regulates | 24715453 | SIGNOR-230733 |
| CSNK1E | PER3 | – | phosphorylation down-regulates quantity by destabilization | 11865049 | SIGNOR-267996 | |
| CSNK1E | WWTR1 | Ser314 | SREQSTDsGLGLGCY | phosphorylation down-regulates | 24715453 | SIGNOR-230747 |
| CSNK1E | BID | Ser64 | LQTDGNRsSHSRLGR | phosphorylation up-regulates activity | 11583622 | SIGNOR-250805 |
| CSNK1E | PER2 | – | phosphorylation down-regulates quantity by destabilization | 17525164 | SIGNOR-276065 | |
| CSNK1E | BID | Thr59 | EGYDELQtDGNRSSH | phosphorylation up-regulates activity | 11583622 | SIGNOR-250806 |
| CSNK1E | CTNND1 | Ser268 | PQVRVGGsSVDLHRF | phosphorylation down-regulates | 3133391 | SIGNOR-24443 |
| CSNK1E | PER3 | Ser622 | ILSTAMLsLGSGISQ | phosphorylation down-regulates activity | 11865049 | SIGNOR-250815 |
| CSNK1E | PER2 | Ser480 | PVPHSGSsGYGSLGS | phosphorylation down-regulates quantity by destabilization | 30425162 | SIGNOR-277419 |
| CSNK1E | TRAF3 | Ser349 | QNWEEADsMKSSVES | phosphorylation up-regulates activity | 26928339 | SIGNOR-277212 |
| CSNK1E | PER1 | – | phosphorylation down-regulates quantity by destabilization | 11865049 | SIGNOR-267997 | |
| CSNK1E | PER1 | – | phosphorylation down-regulates | 15917222 | SIGNOR-137706 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | phosphorylation up-regulates → | LRP6 PSer1430 | phosphorylation up-regulates → | LRP6 | 16513652 | SIGNOR-145053 |
| CSNK1E | phosphorylation up-regulates → | YAP1 PSer403 | phosphorylation down-regulates ⊣ | YAP1 | 23431053 | SIGNOR-201170 |
| CSNK1E | phosphorylation up-regulates → | TRAF3 PTyr116 | phosphorylation up-regulates → | TRAF3 | 32779804 | SIGNOR-277525 |
| CSNK1E | phosphorylation up-regulates → | DVL2 PThr224 | phosphorylation up-regulates → | DVL2 | 22609948 | SIGNOR-197555 |
| CSNK1E | phosphorylation up-regulates → | CSNK1E PThr334 | phosphorylation down-regulates ⊣ | CSNK1E | 10542239 | SIGNOR-250812 |
| CSNK1E | phosphorylation up-regulates → | DVL3 PSer311 | phosphorylation down-regulates ⊣ | DVL3 | 24993822 | SIGNOR-276647 |
| CSNK1E | phosphorylation up-regulates → | LRP6 PSer1420 | phosphorylation up-regulates → | LRP6 | 16513652 | SIGNOR-145049 |
| CSNK1E | phosphorylation up-regulates → | PER3 PSer628 | phosphorylation down-regulates ⊣ | PER3 | 11865049 | SIGNOR-250817 |
| CSNK1E | phosphorylation up-regulates → | CSNK1E PSer323 | phosphorylation down-regulates ⊣ | CSNK1E | 10542239 | SIGNOR-250807 |
| CSNK1E | phosphorylation up-regulates → | EIF4EBP1 PThr50 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 24247720 | SIGNOR-203276 |
| CSNK1E | phosphorylation up-regulates → | PER3 PSer625 | phosphorylation down-regulates ⊣ | PER3 | 11865049 | SIGNOR-250816 |
| CSNK1E | phosphorylation up-regulates → | EIF4EBP1 PThr41 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 24247720 | SIGNOR-203240 |
| CSNK1E | phosphorylation up-regulates → | CSNK1E PThr337 | phosphorylation down-regulates ⊣ | CSNK1E | 10542239 | SIGNOR-250813 |
| CSNK1E | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12176352 | SIGNOR-244102 |
| CSNK1E | phosphorylation up-regulates → | CSNK1E PThr407 | phosphorylation down-regulates ⊣ | CSNK1E | 10542239 | SIGNOR-250814 |
| CSNK1E | phosphorylation up-regulates → | CSNK1E PThr325 | phosphorylation down-regulates ⊣ | CSNK1E | 10542239 | SIGNOR-250811 |
| CSNK1E | phosphorylation up-regulates → | APC PSer1279 | phosphorylation up-regulates → | APC | 11487578 | SIGNOR-109660 |
| CSNK1E | phosphorylation up-regulates → | DVL1 PSer139 | phosphorylation up-regulates → | DVL1 | 16965538 | SIGNOR-217845 |
| CSNK1E | phosphorylation up-regulates → | DVL3 PSer280 | phosphorylation down-regulates ⊣ | DVL3 | 24993822 | SIGNOR-276645 |
| CSNK1E | phosphorylation up-regulates → | PER3 PSer634 | phosphorylation down-regulates ⊣ | PER3 | 11865049 | SIGNOR-250819 |
| CSNK1E | phosphorylation up-regulates → | TRAF3 PTyr446 | phosphorylation up-regulates → | TRAF3 | 32779804 | SIGNOR-277524 |
| CSNK1E | phosphorylation up-regulates → | CDH1 PSer844 | phosphorylation down-regulates ⊣ | CDH1 | 17353278 | SIGNOR-274047 |
| CSNK1E | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12000790 | SIGNOR-87448 |
| CSNK1E | phosphorylation up-regulates → | DVL1 PSer142 | phosphorylation up-regulates → | DVL1 | 16965538 | SIGNOR-217849 |
| CSNK1E | phosphorylation up-regulates → | PER3 PThr635 | phosphorylation down-regulates ⊣ | PER3 | 11865049 | SIGNOR-250820 |
| CSNK1E | phosphorylation up-regulates → | DVL2 PSer143 | phosphorylation up-regulates → | DVL2 | 22609948 | SIGNOR-197063 |
| CSNK1E | phosphorylation up-regulates → | PER3 PSer633 | phosphorylation down-regulates ⊣ | PER3 | 11865049 | SIGNOR-250818 |
| CSNK1E | phosphorylation up-regulates → | CSNK1E PSer405 | phosphorylation down-regulates ⊣ | CSNK1E | 10542239 | SIGNOR-250809 |
| CSNK1E | phosphorylation up-regulates → | YAP1 PSer400 | phosphorylation down-regulates ⊣ | YAP1 | 23431053 | SIGNOR-201165 |
| CSNK1E | phosphorylation up-regulates → | YAP1 PSer400 | phosphorylation down-regulates ⊣ | YAP1 | 24715453 | SIGNOR-230728 |
| CSNK1E | phosphorylation up-regulates → | CSNK1E PSer368 | phosphorylation down-regulates ⊣ | CSNK1E | 10542239 | SIGNOR-250808 |
| CSNK1E | phosphorylation up-regulates → | CSNK1E PSer408 | phosphorylation down-regulates ⊣ | CSNK1E | 10542239 | SIGNOR-250810 |
| CSNK1E | phosphorylation up-regulates → | APC PSer1392 | phosphorylation up-regulates → | APC | 11487578 | SIGNOR-109664 |
| CSNK1E | phosphorylation up-regulates → | YAP1 PSer403 | phosphorylation down-regulates ⊣ | YAP1 | 24715453 | SIGNOR-230733 |
| CSNK1E | phosphorylation up-regulates → | WWTR1 PSer314 | phosphorylation down-regulates ⊣ | WWTR1 | 24715453 | SIGNOR-230747 |
| CSNK1E | phosphorylation up-regulates → | BID PSer64 | phosphorylation up-regulates → | BID | 11583622 | SIGNOR-250805 |
| CSNK1E | phosphorylation up-regulates → | BID PThr59 | phosphorylation up-regulates → | BID | 11583622 | SIGNOR-250806 |
| CSNK1E | phosphorylation up-regulates → | CTNND1 PSer268 | phosphorylation down-regulates ⊣ | CTNND1 | 3133391 | SIGNOR-24443 |
| CSNK1E | phosphorylation up-regulates → | PER3 PSer622 | phosphorylation down-regulates ⊣ | PER3 | 11865049 | SIGNOR-250815 |
| CSNK1E | phosphorylation up-regulates → | PER2 PSer480 | phosphorylation down-regulates ⊣ | PER2 | 30425162 | SIGNOR-277419 |
| CSNK1E | phosphorylation up-regulates → | TRAF3 PSer349 | phosphorylation up-regulates → | TRAF3 | 26928339 | SIGNOR-277212 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1E | phosphorylation → up-regulates | LRP6 | SIGNOR-145053 |
| CSNK1E | phosphorylation down-regulates | YAP1 | SIGNOR-201170 |
| CSNK1E | phosphorylation → up-regulates activity | TRAF3 | SIGNOR-277525 |
| CSNK1E | phosphorylation → up-regulates | DVL2 | SIGNOR-197555 |
| CSNK1E | phosphorylation → down-regulates activity | CSNK1E | SIGNOR-250812 |
| CSNK1E | phosphorylation → down-regulates activity | DVL3 | SIGNOR-276647 |
| CSNK1E | phosphorylation → up-regulates | LRP6 | SIGNOR-145049 |
| CSNK1E | phosphorylation → down-regulates activity | PER3 | SIGNOR-250817 |
| CSNK1E | phosphorylation → down-regulates activity | CSNK1E | SIGNOR-250807 |
| CSNK1E | phosphorylation down-regulates | EIF4EBP1 | SIGNOR-203276 |
| CSNK1E | phosphorylation → down-regulates activity | PER3 | SIGNOR-250816 |
| CSNK1E | phosphorylation down-regulates | EIF4EBP1 | SIGNOR-203240 |
| CSNK1E | phosphorylation → down-regulates activity | CSNK1E | SIGNOR-250813 |
| CSNK1E | phosphorylation down-regulates | LEF1 | SIGNOR-134497 |
| CSNK1E | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-244102 |
| CSNK1E | phosphorylation → down-regulates activity | CSNK1E | SIGNOR-250814 |
| CSNK1E | phosphorylation → down-regulates activity | CSNK1E | SIGNOR-250811 |
| CSNK1E | phosphorylation → up-regulates activity | APC | SIGNOR-109660 |
| CSNK1E | phosphorylation → up-regulates | GSK3B/Axin/APC | SIGNOR-227976 |
| CSNK1E | phosphorylation → up-regulates activity | DVL1 | SIGNOR-217845 |
| CSNK1E | phosphorylation → down-regulates activity | DVL3 | SIGNOR-276645 |
| CSNK1E | phosphorylation → down-regulates activity | PER3 | SIGNOR-250819 |
| CSNK1E | phosphorylation → up-regulates activity | TRAF3 | SIGNOR-277524 |
| CSNK1E | phosphorylation → up-regulates activity | PPP1R1B | SIGNOR-279701 |
| CSNK1E | phosphorylation → down-regulates activity | CDH1 | SIGNOR-274047 |
| CSNK1E | phosphorylation → up-regulates | ROR2 | SIGNOR-129117 |
| CSNK1E | phosphorylation down-regulates | CTNNB1 | SIGNOR-87448 |
| CSNK1E | phosphorylation → up-regulates activity | DVL1 | SIGNOR-217849 |
| CSNK1E | phosphorylation → down-regulates activity | PER3 | SIGNOR-250820 |
| CSNK1E | phosphorylation → up-regulates | DVL2 | SIGNOR-197063 |
| CSNK1E | phosphorylation → up-regulates | AXIN1 | SIGNOR-87444 |
| CSNK1E | phosphorylation → down-regulates activity | PER3 | SIGNOR-250818 |
| CSNK1E | phosphorylation → down-regulates activity | CSNK1E | SIGNOR-250809 |
| CSNK1E | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-267995 |
| CSNK1E | phosphorylation down-regulates | YAP1 | SIGNOR-201165 |
| CSNK1E | phosphorylation → up-regulates activity | DVL2 | SIGNOR-244097 |
| CSNK1E | phosphorylation down-regulates | YAP1 | SIGNOR-230728 |
| CSNK1E | phosphorylation → down-regulates activity | CSNK1E | SIGNOR-250808 |
| CSNK1E | phosphorylation → down-regulates activity | CSNK1E | SIGNOR-250810 |
| CSNK1E | phosphorylation → up-regulates activity | APC | SIGNOR-109664 |
| CSNK1E | phosphorylation → up-regulates | TCF3 | SIGNOR-110056 |
| CSNK1E | phosphorylation down-regulates | YAP1 | SIGNOR-230733 |
| CSNK1E | phosphorylation down-regulates quantity by destabilization | PER3 | SIGNOR-267996 |
| CSNK1E | phosphorylation down-regulates | WWTR1 | SIGNOR-230747 |
| CSNK1E | phosphorylation → up-regulates activity | BID | SIGNOR-250805 |
| CSNK1E | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-276065 |
| CSNK1E | phosphorylation → up-regulates activity | BID | SIGNOR-250806 |
| CSNK1E | phosphorylation down-regulates | CTNND1 | SIGNOR-24443 |
| CSNK1E | phosphorylation → down-regulates activity | PER3 | SIGNOR-250815 |
| CSNK1E | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-277419 |
| CSNK1E | phosphorylation → up-regulates activity | TRAF3 | SIGNOR-277212 |
| CSNK1E | phosphorylation down-regulates quantity by destabilization | PER1 | SIGNOR-267997 |
| CSNK1E | phosphorylation down-regulates | PER1 | SIGNOR-137706 |