| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC7 | MCM2 | Ser108 | DVEELTAsQREAAER | phosphorylation up-regulates | 19647517 | SIGNOR-187388 |
| CDC7 | MCM2 | Ser40 | RRTDALTsSPGRDLP | phosphorylation up-regulates | 19647517 | SIGNOR-187392 |
| CDC7 | MCM2 | Ser27 | GNDPLTSsPGRSSRR | phosphorylation up-regulates | 16446360 | SIGNOR-143992 |
| CDK7 | MCM2 | Ser139 | RRGLLYDsDEEDEER | phosphorylation up-regulates activity | 16899510 | SIGNOR-259850 |
| CDK2 | MCM2 | Ser13 | ESFTMASsPAQRRRG | phosphorylation up-regulates | 16446360 | SIGNOR-144000 |
| CSNK2A1 | MCM2 | Ser13 | ESFTMASsPAQRRRG | phosphorylation up-regulates | 16446360 | SIGNOR-144004 |
| ATR | MCM2 | Ser108 | DVEELTAsQREAAER | phosphorylation unknown | 15210935 | SIGNOR-126363 |
| CDC7 | MCM2 | Ser41 | RTDALTSsPGRDLPP | phosphorylation up-regulates | 16899510 | SIGNOR-148717 |
| CDK7 | MCM2 | Ser27 | GNDPLTSsPGRSSRR | phosphorylation up-regulates activity | 16899510 | SIGNOR-259848 |
| CDC7 | MCM2 | Ser27 | GNDPLTSsPGRSSRR | phosphorylation up-regulates | 16899510 | SIGNOR-148713 |
| CDC7 | MCM2 | Ser139 | RRGLLYDsDEEDEER | phosphorylation up-regulates | 16899510 | SIGNOR-148709 |
| CDC7 | MCM2 | Ser41 | RTDALTSsPGRDLPP | phosphorylation up-regulates | 16446360 | SIGNOR-143996 |
| CDC7 | MCM2 | Ser13 | ESFTMASsPAQRRRG | phosphorylation up-regulates | 16446360 | SIGNOR-143984 |
| CDC7 | MCM2 | Ser53 | LPPFEDEsEGLLGTE | phosphorylation up-regulates | 19647517 | SIGNOR-187400 |
| CDK7 | MCM2 | Ser41 | RTDALTSsPGRDLPP | phosphorylation up-regulates activity | 16899510 | SIGNOR-259849 |
| CDC7 | MCM2 | Ser5 | sESFTMAS | phosphorylation up-regulates | 19647517 | SIGNOR-187396 |
| CDC7 | MCM2 | Ser139 | RRGLLYDsDEEDEER | phosphorylation up-regulates | 16446360 | SIGNOR-143988 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC7 | phosphorylation up-regulates → | MCM2 PSer108 | phosphorylation up-regulates → | MCM2 | 19647517 | SIGNOR-187388 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer40 | phosphorylation up-regulates → | MCM2 | 19647517 | SIGNOR-187392 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer27 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-143992 |
| CDK7 | phosphorylation up-regulates → | MCM2 PSer139 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-259850 |
| CDK2 | phosphorylation up-regulates → | MCM2 PSer13 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-144000 |
| CSNK2A1 | phosphorylation up-regulates → | MCM2 PSer13 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-144004 |
| ATR | phosphorylation up-regulates → | MCM2 PSer108 | phosphorylation down-regulates ⊣ | MCM2 | 15210935 | SIGNOR-126363 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer41 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-148717 |
| CDK7 | phosphorylation up-regulates → | MCM2 PSer27 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-259848 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer27 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-148713 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer139 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-148709 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer41 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-143996 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer13 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-143984 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer53 | phosphorylation up-regulates → | MCM2 | 19647517 | SIGNOR-187400 |
| CDK7 | phosphorylation up-regulates → | MCM2 PSer41 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-259849 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer5 | phosphorylation up-regulates → | MCM2 | 19647517 | SIGNOR-187396 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer139 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-143988 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-187388 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-187392 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-143992 |
| CDK7 | phosphorylation → up-regulates activity | MCM2 | SIGNOR-259850 |
| CDK2 | phosphorylation → up-regulates | MCM2 | SIGNOR-144000 |
| CSNK2A1 | phosphorylation → up-regulates | MCM2 | SIGNOR-144004 |
| ATR | phosphorylation → unknown | MCM2 | SIGNOR-126363 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-148717 |
| CDK7 | phosphorylation → up-regulates activity | MCM2 | SIGNOR-259848 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-148713 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-148709 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-143996 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-143984 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-187400 |
| CDK7 | phosphorylation → up-regulates activity | MCM2 | SIGNOR-259849 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-187396 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-143988 |
