Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK7	MCM2	Ser139 View in OncoXplorer	RRGLLYDsDEEDEER	phosphorylation up-regulates activity	16899510	SIGNOR-259850
CDC7	MCM2	Ser139 View in OncoXplorer	RRGLLYDsDEEDEER	phosphorylation up-regulates	16899510	SIGNOR-148709
CDC7	MCM2	Ser139 View in OncoXplorer	RRGLLYDsDEEDEER	phosphorylation up-regulates	16446360	SIGNOR-143988

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK7	phosphorylation up-regulates →	MCM2 PSer139	phosphorylation up-regulates →	MCM2	16899510	SIGNOR-259850
CDC7	phosphorylation up-regulates →	MCM2 PSer139	phosphorylation up-regulates →	MCM2	16899510	SIGNOR-148709
CDC7	phosphorylation up-regulates →	MCM2 PSer139	phosphorylation up-regulates →	MCM2	16446360	SIGNOR-143988

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK7	phosphorylation → up-regulates activity	MCM2	SIGNOR-259850
CDC7	phosphorylation → up-regulates	MCM2	SIGNOR-148709
CDC7	phosphorylation → up-regulates	MCM2	SIGNOR-143988