Entity Details

Name	MCM2_Ser27
ID	P49736
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDC7	MCM2	Ser27 View in OncoXplorer	GNDPLTSsPGRSSRR	phosphorylation up-regulates	16899510	SIGNOR-148713
CDK7	MCM2	Ser27 View in OncoXplorer	GNDPLTSsPGRSSRR	phosphorylation up-regulates activity	16899510	SIGNOR-259848
CDC7	MCM2	Ser27 View in OncoXplorer	GNDPLTSsPGRSSRR	phosphorylation up-regulates	16446360	SIGNOR-143992

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDC7	phosphorylation up-regulates →	MCM2 PSer27	phosphorylation up-regulates →	MCM2	16899510	SIGNOR-148713
CDK7	phosphorylation up-regulates →	MCM2 PSer27	phosphorylation up-regulates →	MCM2	16899510	SIGNOR-259848
CDC7	phosphorylation up-regulates →	MCM2 PSer27	phosphorylation up-regulates →	MCM2	16446360	SIGNOR-143992

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDC7	phosphorylation → up-regulates	MCM2	SIGNOR-148713
CDK7	phosphorylation → up-regulates activity	MCM2	SIGNOR-259848
CDC7	phosphorylation → up-regulates	MCM2	SIGNOR-143992