Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CLK1	ABL1	Thr735	DTEWRSVtLPRDLQS	phosphorylation down-regulates	18794806	SIGNOR-181031
CLK1	PTPN1	Ser242	MDKRKDPsSVDIKKV	phosphorylation up-regulates activity	10480872	SIGNOR-250773
CLK1	PTPN1	Ser243	DKRKDPSsVDIKKVL	phosphorylation up-regulates activity	10480872	SIGNOR-250774
CLK1	PTPN1	Ser50	RNRYRDVsPFDHSRI	phosphorylation up-regulates activity	10480872	SIGNOR-70563
CLK1	SRSF1	–		phosphorylation up-regulates activity	23707382	SIGNOR-279608
CLK1	SRSF1	–		phosphorylation up-regulates activity	8617202	SIGNOR-273857
CLK1	RBM17	Ser202	EEDSRPRsQSSKAAI	phosphorylation up-regulates activity	23519612	SIGNOR-262705
CLK1	RBM17	Ser204	DSRPRSQsSKAAIPP	phosphorylation up-regulates activity	23519612	SIGNOR-262706
CLK1	RBM17	Ser222	EEQDRPRsPTGPSNS	phosphorylation up-regulates activity	23519612	SIGNOR-262707
CLK1	RBM17	Ser266	QGLSTALsVEKTSKR	phosphorylation up-regulates activity	23519612	SIGNOR-262708
CLK1	RBM17	Ser288	DATEKDAsKKSDSNP	phosphorylation up-regulates activity	23519612	SIGNOR-262709
CLK1	RBM17	Ser291	EKDASKKsDSNPLTE	phosphorylation up-regulates activity	23519612	SIGNOR-262710
CLK1	RBM17	Ser48	KSQRTKQsTVLAPVI	phosphorylation up-regulates activity	23519612	SIGNOR-262711
CLK1	RBM17	Ser62	IDLKRGGsSDDRQIV	phosphorylation up-regulates activity	23519612	SIGNOR-262712

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CLK1	phosphorylation up-regulates →	ABL1 PThr735	phosphorylation down-regulates ⊣	ABL1	18794806	SIGNOR-181031
CLK1	phosphorylation up-regulates →	PTPN1 PSer242	phosphorylation up-regulates →	PTPN1	10480872	SIGNOR-250773
CLK1	phosphorylation up-regulates →	PTPN1 PSer243	phosphorylation up-regulates →	PTPN1	10480872	SIGNOR-250774
CLK1	phosphorylation up-regulates →	PTPN1 PSer50	phosphorylation up-regulates →	PTPN1	10480872	SIGNOR-70563
CLK1	phosphorylation up-regulates →	RBM17 PSer202	phosphorylation up-regulates →	RBM17	23519612	SIGNOR-262705
CLK1	phosphorylation up-regulates →	RBM17 PSer204	phosphorylation up-regulates →	RBM17	23519612	SIGNOR-262706
CLK1	phosphorylation up-regulates →	RBM17 PSer222	phosphorylation up-regulates →	RBM17	23519612	SIGNOR-262707
CLK1	phosphorylation up-regulates →	RBM17 PSer266	phosphorylation up-regulates →	RBM17	23519612	SIGNOR-262708
CLK1	phosphorylation up-regulates →	RBM17 PSer288	phosphorylation up-regulates →	RBM17	23519612	SIGNOR-262709
CLK1	phosphorylation up-regulates →	RBM17 PSer291	phosphorylation up-regulates →	RBM17	23519612	SIGNOR-262710
CLK1	phosphorylation up-regulates →	RBM17 PSer48	phosphorylation up-regulates →	RBM17	23519612	SIGNOR-262711
CLK1	phosphorylation up-regulates →	RBM17 PSer62	phosphorylation up-regulates →	RBM17	23519612	SIGNOR-262712

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CLK1	phosphorylation down-regulates	ABL1	SIGNOR-181031
CLK1	phosphorylation → up-regulates activity	PTPN1	SIGNOR-250773
CLK1	phosphorylation → up-regulates activity	PTPN1	SIGNOR-250774
CLK1	phosphorylation → up-regulates activity	PTPN1	SIGNOR-70563
CLK1	phosphorylation → up-regulates activity	SRSF1	SIGNOR-279608
CLK1	phosphorylation → up-regulates activity	SRSF1	SIGNOR-273857
CLK1	phosphorylation → up-regulates activity	RBM17	SIGNOR-262705
CLK1	phosphorylation → up-regulates activity	RBM17	SIGNOR-262706
CLK1	phosphorylation → up-regulates activity	RBM17	SIGNOR-262707
CLK1	phosphorylation → up-regulates activity	RBM17	SIGNOR-262708
CLK1	phosphorylation → up-regulates activity	RBM17	SIGNOR-262709
CLK1	phosphorylation → up-regulates activity	RBM17	SIGNOR-262710
CLK1	phosphorylation → up-regulates activity	RBM17	SIGNOR-262711
CLK1	phosphorylation → up-regulates activity	RBM17	SIGNOR-262712