| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249239 |
| GSK3B/Axin/APC | PSEN1 | Ser357 | PHRSTPEsRAAVQEL | phosphorylation down-regulates activity | 17360711 | SIGNOR-228022 |
| GSK3B | PSEN1 | Ser353 | SHLGPHRsTPESRAA | phosphorylation down-regulates activity | 17360711 | SIGNOR-153627 |
| GSK3B | PSEN1 | Ser357 | PHRSTPEsRAAVQEL | phosphorylation down-regulates activity | 17360711 | SIGNOR-153631 |
| GSK3B/Axin/APC | PSEN1 | Ser353 | SHLGPHRsTPESRAA | phosphorylation down-regulates activity | 17360711 | SIGNOR-228018 |
| PRKCB | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249237 |
| CDK5 | PSEN1 | Thr354 | HLGPHRStPESRAAV | phosphorylation up-regulates | 12056836 | SIGNOR-89145 |
| PRKACA | PSEN1 | Ser310 | PEAQRRVsKNSKYNA | phosphorylation unknown | 14576165 | SIGNOR-250036 |
| MAPK9 | PSEN1 | Thr320 | SKYNAEStERESQDT | phosphorylation up-regulates | 18667537 | SIGNOR-179680 |
| PRKCA | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249236 |
| MAPK9 | PSEN1 | Ser319 | NSKYNAEsTERESQD | phosphorylation up-regulates | 18667537 | SIGNOR-179676 |
| PRKCG | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249238 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249239 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | PSEN1 PSer357 | phosphorylation down-regulates ⊣ | PSEN1 | 17360711 | SIGNOR-228022 |
| GSK3B | phosphorylation up-regulates → | PSEN1 PSer353 | phosphorylation down-regulates ⊣ | PSEN1 | 17360711 | SIGNOR-153627 |
| GSK3B | phosphorylation up-regulates → | PSEN1 PSer357 | phosphorylation down-regulates ⊣ | PSEN1 | 17360711 | SIGNOR-153631 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | PSEN1 PSer353 | phosphorylation down-regulates ⊣ | PSEN1 | 17360711 | SIGNOR-228018 |
| PRKCB | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249237 |
| CDK5 | phosphorylation up-regulates → | PSEN1 PThr354 | phosphorylation up-regulates → | PSEN1 | 12056836 | SIGNOR-89145 |
| PRKACA | phosphorylation up-regulates → | PSEN1 PSer310 | phosphorylation down-regulates ⊣ | PSEN1 | 14576165 | SIGNOR-250036 |
| MAPK9 | phosphorylation up-regulates → | PSEN1 PThr320 | phosphorylation up-regulates → | PSEN1 | 18667537 | SIGNOR-179680 |
| PRKCA | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249236 |
| MAPK9 | phosphorylation up-regulates → | PSEN1 PSer319 | phosphorylation up-regulates → | PSEN1 | 18667537 | SIGNOR-179676 |
| PRKCG | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249238 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249239 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | PSEN1 | SIGNOR-228022 |
| GSK3B | phosphorylation → down-regulates activity | PSEN1 | SIGNOR-153627 |
| GSK3B | phosphorylation → down-regulates activity | PSEN1 | SIGNOR-153631 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | PSEN1 | SIGNOR-228018 |
| PRKCB | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249237 |
| CDK5 | phosphorylation → up-regulates | PSEN1 | SIGNOR-89145 |
| PRKACA | phosphorylation → unknown | PSEN1 | SIGNOR-250036 |
| MAPK9 | phosphorylation → up-regulates | PSEN1 | SIGNOR-179680 |
| PRKCA | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249236 |
| MAPK9 | phosphorylation → up-regulates | PSEN1 | SIGNOR-179676 |
| PRKCG | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249238 |
