Entity Details

Name GSK3B/Axin/APC_Ser353
ID P49768
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BPSEN1Ser353SHLGPHRsTPESRAAphosphorylation
down-regulates activity		17360711SIGNOR-153627
GSK3B/Axin/APCPSEN1Ser353SHLGPHRsTPESRAAphosphorylation
down-regulates activity		17360711SIGNOR-228018
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
PSEN1
PSer353		phosphorylation
down-regulates
⊣		PSEN117360711SIGNOR-153627
GSK3B/Axin/APCphosphorylation
up-regulates
→
PSEN1
PSer353		phosphorylation
down-regulates
⊣		PSEN117360711SIGNOR-228018
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
→
down-regulates activity 		PSEN1SIGNOR-153627
GSK3B/Axin/APCphosphorylation
→
down-regulates activity 		PSEN1SIGNOR-228018