| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249239 |
| PRKCG | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249238 |
| PRKCB | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249237 |
| PRKCA | PSEN1 | Ser346 | EWEAQRDsHLGPHRS | phosphorylation up-regulates activity | 14576165 | SIGNOR-249236 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249239 |
| PRKCG | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249238 |
| PRKCB | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249237 |
| PRKCA | phosphorylation up-regulates → | PSEN1 PSer346 | phosphorylation up-regulates → | PSEN1 | 14576165 | SIGNOR-249236 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249239 |
| PRKCG | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249238 |
| PRKCB | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249237 |
| PRKCA | phosphorylation → up-regulates activity | PSEN1 | SIGNOR-249236 |