| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | PSEN2 | Ser19 | EVCDERTsLMSAESP | phosphorylation unknown | 8972483 | SIGNOR-250799 |
| CSNK1A1 | PSEN2 | Ser19 | EVCDERTsLMSAESP | phosphorylation unknown | 8972483 | SIGNOR-250790 |
| CSNK1A1 | PSEN2 | Ser7 | sDSEEEVC | phosphorylation unknown | 8972483 | SIGNOR-250791 |
| CSNK2A1 | PSEN2 | Ser335 | YDSFGEPsYPEVFEP | phosphorylation up-regulates activity | 9558331 | SIGNOR-250935 |
| CSNK1A1 | PSEN2 | Ser9 | LTFMASDsEEEVCDE | phosphorylation unknown | 8972483 | SIGNOR-250792 |
| CSNK1D | PSEN2 | Ser327 | DPEMEEDsYDSFGEP | phosphorylation up-regulates activity | 9558331 | SIGNOR-250800 |
| CSNK1D | PSEN2 | Ser7 | sDSEEEVC | phosphorylation unknown | 8972483 | SIGNOR-250803 |
| CSNK2A1 | PSEN2 | Ser19 | EVCDERTsLMSAESP | phosphorylation unknown | 8972483 | SIGNOR-250932 |
| CSNK1D | PSEN2 | Ser9 | LTFMASDsEEEVCDE | phosphorylation unknown | 8972483 | SIGNOR-250804 |
| CSNK2A1 | PSEN2 | Ser7 | sDSEEEVC | phosphorylation unknown | 8972483 | SIGNOR-250936 |
| CSNK2A1 | PSEN2 | Ser327 | DPEMEEDsYDSFGEP | phosphorylation up-regulates activity | 9558331 | SIGNOR-250933 |
| CSNK2A1 | PSEN2 | Ser330 | MEEDSYDsFGEPSYP | phosphorylation up-regulates activity | 9558331 | SIGNOR-250934 |
| CSNK1D | PSEN2 | Ser335 | YDSFGEPsYPEVFEP | phosphorylation up-regulates activity | 9558331 | SIGNOR-250802 |
| CSNK1D | PSEN2 | Ser330 | MEEDSYDsFGEPSYP | phosphorylation up-regulates activity | 9558331 | SIGNOR-250801 |
| CSNK2A1 | PSEN2 | Ser9 | LTFMASDsEEEVCDE | phosphorylation unknown | 8972483 | SIGNOR-250937 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | phosphorylation up-regulates → | PSEN2 PSer19 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250799 |
| CSNK1A1 | phosphorylation up-regulates → | PSEN2 PSer19 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250790 |
| CSNK1A1 | phosphorylation up-regulates → | PSEN2 PSer7 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250791 |
| CSNK2A1 | phosphorylation up-regulates → | PSEN2 PSer335 | phosphorylation up-regulates → | PSEN2 | 9558331 | SIGNOR-250935 |
| CSNK1A1 | phosphorylation up-regulates → | PSEN2 PSer9 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250792 |
| CSNK1D | phosphorylation up-regulates → | PSEN2 PSer327 | phosphorylation up-regulates → | PSEN2 | 9558331 | SIGNOR-250800 |
| CSNK1D | phosphorylation up-regulates → | PSEN2 PSer7 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250803 |
| CSNK2A1 | phosphorylation up-regulates → | PSEN2 PSer19 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250932 |
| CSNK1D | phosphorylation up-regulates → | PSEN2 PSer9 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250804 |
| CSNK2A1 | phosphorylation up-regulates → | PSEN2 PSer7 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250936 |
| CSNK2A1 | phosphorylation up-regulates → | PSEN2 PSer327 | phosphorylation up-regulates → | PSEN2 | 9558331 | SIGNOR-250933 |
| CSNK2A1 | phosphorylation up-regulates → | PSEN2 PSer330 | phosphorylation up-regulates → | PSEN2 | 9558331 | SIGNOR-250934 |
| CSNK1D | phosphorylation up-regulates → | PSEN2 PSer335 | phosphorylation up-regulates → | PSEN2 | 9558331 | SIGNOR-250802 |
| CSNK1D | phosphorylation up-regulates → | PSEN2 PSer330 | phosphorylation up-regulates → | PSEN2 | 9558331 | SIGNOR-250801 |
| CSNK2A1 | phosphorylation up-regulates → | PSEN2 PSer9 | phosphorylation down-regulates ⊣ | PSEN2 | 8972483 | SIGNOR-250937 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1D | phosphorylation → unknown | PSEN2 | SIGNOR-250799 |
| CSNK1A1 | phosphorylation → unknown | PSEN2 | SIGNOR-250790 |
| CSNK1A1 | phosphorylation → unknown | PSEN2 | SIGNOR-250791 |
| CSNK2A1 | phosphorylation → up-regulates activity | PSEN2 | SIGNOR-250935 |
| CSNK1A1 | phosphorylation → unknown | PSEN2 | SIGNOR-250792 |
| CSNK1D | phosphorylation → up-regulates activity | PSEN2 | SIGNOR-250800 |
| CSNK1D | phosphorylation → unknown | PSEN2 | SIGNOR-250803 |
| CSNK2A1 | phosphorylation → unknown | PSEN2 | SIGNOR-250932 |
| CSNK1D | phosphorylation → unknown | PSEN2 | SIGNOR-250804 |
| CSNK2A1 | phosphorylation → unknown | PSEN2 | SIGNOR-250936 |
| CSNK2A1 | phosphorylation → up-regulates activity | PSEN2 | SIGNOR-250933 |
| CSNK2A1 | phosphorylation → up-regulates activity | PSEN2 | SIGNOR-250934 |
| CSNK1D | phosphorylation → up-regulates activity | PSEN2 | SIGNOR-250802 |
| CSNK1D | phosphorylation → up-regulates activity | PSEN2 | SIGNOR-250801 |
| CSNK2A1 | phosphorylation → unknown | PSEN2 | SIGNOR-250937 |
