| Name | TSC2 |
| ID | P49815 |
| Role | substrate |
| Enzymatic Domains |
Rap-GAP 1531-1758 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | TSC2 | – | phosphorylation down-regulates activity | 19188143 | SIGNOR-183695 | |
| AMPK | TSC2 | Ser1387 | QPLSKSSsSPELQTL | phosphorylation up-regulates | 16959574 | SIGNOR-216438 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 12172553 | SIGNOR-91388 |
| GSK3A | TSC2 | – | phosphorylation up-regulates | 20226003 | SIGNOR-164098 | |
| RPS6KA1 | TSC2 | Ser1798 | GQRKRLIsSVEDFTE | phosphorylation down-regulates | 15342917 | SIGNOR-128634 |
| GSK3B | TSC2 | – | phosphorylation up-regulates activity | 16959574 | SIGNOR-149380 | |
| MAPK1 | TSC2 | Ser664 | KKTSGPLsPPTGPPG | phosphorylation down-regulates | 15851026 | SIGNOR-135696 |
| SGK1 | TSC2 | Ser1130 | GARDRVRsMSGGHGL | phosphorylation down-regulates activity | 27451907 | SIGNOR-277266 |
| MAPK3 | TSC2 | Ser540 | KVMARSLsPPPELEE | phosphorylation down-regulates activity | 15851026 | SIGNOR-249458 |
| PRKAA1 | TSC2 | – | phosphorylation up-regulates activity | 31235817 | SIGNOR-278981 | |
| SGK3 | TSC2 | – | phosphorylation up-regulates activity | 34911733 | SIGNOR-279284 | |
| Gbeta | TSC2 | – | phosphorylation down-regulates activity | 15851026 | SIGNOR-270108 | |
| AKT1 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates activity | 12150915 | SIGNOR-235511 |
| MAPK3 | TSC2 | Ser664 | KKTSGPLsPPTGPPG | phosphorylation down-regulates activity | 15851026 | SIGNOR-249457 |
| PRKCD | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates activity | 30684133 | SIGNOR-277427 |
| ERK1/2 | TSC2 | Ser540 | KVMARSLsPPPELEE | phosphorylation down-regulates activity | 15851026 | SIGNOR-249455 |
| ERK1/2 | TSC2 | – | phosphorylation down-regulates activity | 19188143 | SIGNOR-244602 | |
| AKT | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates activity | 12150915 | SIGNOR-244365 |
| AKT | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates activity | 12150915 | SIGNOR-244369 |
| PRKAA2 | TSC2 | Ser1387 | QPLSKSSsSPELQTL | phosphorylation up-regulates | 16959574 | SIGNOR-149388 |
| RPS6K | TSC2 | Ser1798 | GQRKRLIsSVEDFTE | phosphorylation down-regulates | 15342917 | SIGNOR-252801 |
| AKT1 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates activity | 12150915 | SIGNOR-235515 |
| ERK1/2 | TSC2 | Ser664 | KKTSGPLsPPTGPPG | phosphorylation down-regulates | 15851026 | SIGNOR-244765 |
| CyclinD1/CDK6 | TSC2 | Ser1217 | MSLENPLsPFSSDIN | phosphorylation up-regulates activity | 32294430 | SIGNOR-274101 |
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 12172553 | SIGNOR-91392 |
| CyclinD/CDK4 | TSC2 | Ser1452 | LPSSSPRsPSGLRPR | phosphorylation up-regulates activity | 32294430 | SIGNOR-274100 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 12150915 | SIGNOR-91041 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 19188143 | SIGNOR-183636 |
| MAPK1 | TSC2 | Ser540 | KVMARSLsPPPELEE | phosphorylation down-regulates activity | 15851026 | SIGNOR-249454 |
| CyclinD/CDK4 | TSC2 | Ser1217 | MSLENPLsPFSSDIN | phosphorylation up-regulates activity | 32294430 | SIGNOR-274099 |
| CHUK | TSC2 | – | phosphorylation down-regulates | 18490760 | SIGNOR-178664 | |
| PRKCD | TSC2 | Ser932 | DDTPEKDsFRARSTS | phosphorylation down-regulates activity | 30684133 | SIGNOR-277426 |
| CyclinD1/CDK6 | TSC2 | Ser1452 | LPSSSPRsPSGLRPR | phosphorylation up-regulates activity | 32294430 | SIGNOR-274102 |
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 19188143 | SIGNOR-183640 |
| GSK3A | TSC2 | – | phosphorylation up-regulates | 16959574 | SIGNOR-149377 | |
| MAPKAPK2 | TSC2 | Ser1254 | TALYKSLsVPAASTA | phosphorylation unknown | 12582162 | SIGNOR-98201 |
| SGK1 | TSC2 | Ser1132 | RDRVRSMsGGHGLRV | phosphorylation down-regulates activity | 27451907 | SIGNOR-277265 |
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 12150915 | SIGNOR-91045 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | TSC2 PSer1387 | phosphorylation up-regulates → | TSC2 | 16959574 | SIGNOR-216438 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12172553 | SIGNOR-91388 |
| RPS6KA1 | phosphorylation up-regulates → | TSC2 PSer1798 | phosphorylation down-regulates ⊣ | TSC2 | 15342917 | SIGNOR-128634 |
| MAPK1 | phosphorylation up-regulates → | TSC2 PSer664 | phosphorylation down-regulates ⊣ | TSC2 | 15851026 | SIGNOR-135696 |
| SGK1 | phosphorylation up-regulates → | TSC2 PSer1130 | phosphorylation down-regulates ⊣ | TSC2 | 27451907 | SIGNOR-277266 |
| MAPK3 | phosphorylation up-regulates → | TSC2 PSer540 | phosphorylation down-regulates ⊣ | TSC2 | 15851026 | SIGNOR-249458 |
| AKT1 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-235511 |
| MAPK3 | phosphorylation up-regulates → | TSC2 PSer664 | phosphorylation down-regulates ⊣ | TSC2 | 15851026 | SIGNOR-249457 |
| PRKCD | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 30684133 | SIGNOR-277427 |
| ERK1/2 | phosphorylation up-regulates → | TSC2 PSer540 | phosphorylation down-regulates ⊣ | TSC2 | 15851026 | SIGNOR-249455 |
| AKT | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-244365 |
| AKT | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-244369 |
| PRKAA2 | phosphorylation up-regulates → | TSC2 PSer1387 | phosphorylation up-regulates → | TSC2 | 16959574 | SIGNOR-149388 |
| RPS6K | phosphorylation up-regulates → | TSC2 PSer1798 | phosphorylation down-regulates ⊣ | TSC2 | 15342917 | SIGNOR-252801 |
| AKT1 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-235515 |
| ERK1/2 | phosphorylation up-regulates → | TSC2 PSer664 | phosphorylation down-regulates ⊣ | TSC2 | 15851026 | SIGNOR-244765 |
| CyclinD1/CDK6 | phosphorylation up-regulates → | TSC2 PSer1217 | phosphorylation up-regulates → | TSC2 | 32294430 | SIGNOR-274101 |
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12172553 | SIGNOR-91392 |
| CyclinD/CDK4 | phosphorylation up-regulates → | TSC2 PSer1452 | phosphorylation up-regulates → | TSC2 | 32294430 | SIGNOR-274100 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-91041 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 19188143 | SIGNOR-183636 |
| MAPK1 | phosphorylation up-regulates → | TSC2 PSer540 | phosphorylation down-regulates ⊣ | TSC2 | 15851026 | SIGNOR-249454 |
| CyclinD/CDK4 | phosphorylation up-regulates → | TSC2 PSer1217 | phosphorylation up-regulates → | TSC2 | 32294430 | SIGNOR-274099 |
| PRKCD | phosphorylation up-regulates → | TSC2 PSer932 | phosphorylation down-regulates ⊣ | TSC2 | 30684133 | SIGNOR-277426 |
| CyclinD1/CDK6 | phosphorylation up-regulates → | TSC2 PSer1452 | phosphorylation up-regulates → | TSC2 | 32294430 | SIGNOR-274102 |
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 19188143 | SIGNOR-183640 |
| MAPKAPK2 | phosphorylation up-regulates → | TSC2 PSer1254 | phosphorylation down-regulates ⊣ | TSC2 | 12582162 | SIGNOR-98201 |
| SGK1 | phosphorylation up-regulates → | TSC2 PSer1132 | phosphorylation down-regulates ⊣ | TSC2 | 27451907 | SIGNOR-277265 |
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-91045 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-183695 |
| AMPK | phosphorylation → up-regulates | TSC2 | SIGNOR-216438 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91388 |
| GSK3A | phosphorylation → up-regulates | TSC2 | SIGNOR-164098 |
| RPS6KA1 | phosphorylation down-regulates | TSC2 | SIGNOR-128634 |
| GSK3B | phosphorylation → up-regulates activity | TSC2 | SIGNOR-149380 |
| MAPK1 | phosphorylation down-regulates | TSC2 | SIGNOR-135696 |
| SGK1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-277266 |
| MAPK3 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-249458 |
| PRKAA1 | phosphorylation → up-regulates activity | TSC2 | SIGNOR-278981 |
| SGK3 | phosphorylation → up-regulates activity | TSC2 | SIGNOR-279284 |
| Gbeta | phosphorylation → down-regulates activity | TSC2 | SIGNOR-270108 |
| AKT1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-235511 |
| MAPK3 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-249457 |
| PRKCD | phosphorylation → down-regulates activity | TSC2 | SIGNOR-277427 |
| ERK1/2 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-249455 |
| ERK1/2 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-244602 |
| AKT | phosphorylation → down-regulates activity | TSC2 | SIGNOR-244365 |
| AKT | phosphorylation → down-regulates activity | TSC2 | SIGNOR-244369 |
| PRKAA2 | phosphorylation → up-regulates | TSC2 | SIGNOR-149388 |
| RPS6K | phosphorylation down-regulates | TSC2 | SIGNOR-252801 |
| AKT1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-235515 |
| ERK1/2 | phosphorylation down-regulates | TSC2 | SIGNOR-244765 |
| CyclinD1/CDK6 | phosphorylation → up-regulates activity | TSC2 | SIGNOR-274101 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91392 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | TSC2 | SIGNOR-274100 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91041 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-183636 |
| MAPK1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-249454 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | TSC2 | SIGNOR-274099 |
| CHUK | phosphorylation down-regulates | TSC2 | SIGNOR-178664 |
| PRKCD | phosphorylation → down-regulates activity | TSC2 | SIGNOR-277426 |
| CyclinD1/CDK6 | phosphorylation → up-regulates activity | TSC2 | SIGNOR-274102 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-183640 |
| GSK3A | phosphorylation → up-regulates | TSC2 | SIGNOR-149377 |
| MAPKAPK2 | phosphorylation → unknown | TSC2 | SIGNOR-98201 |
| SGK1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-277265 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91045 |