| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates activity | 12150915 | SIGNOR-235511 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 12172553 | SIGNOR-91388 |
| PRKCD | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates activity | 30684133 | SIGNOR-277427 |
| AKT | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates activity | 12150915 | SIGNOR-244369 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 12150915 | SIGNOR-91041 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 19188143 | SIGNOR-183636 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-235511 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12172553 | SIGNOR-91388 |
| PRKCD | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 30684133 | SIGNOR-277427 |
| AKT | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-244369 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-91041 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 19188143 | SIGNOR-183636 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-235511 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91388 |
| PRKCD | phosphorylation → down-regulates activity | TSC2 | SIGNOR-277427 |
| AKT | phosphorylation → down-regulates activity | TSC2 | SIGNOR-244369 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91041 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-183636 |
