| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 19188143 | SIGNOR-183640 |
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 12150915 | SIGNOR-91045 |
| AKT | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates activity | 12150915 | SIGNOR-244365 |
| AKT1 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates activity | 12150915 | SIGNOR-235515 |
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 12172553 | SIGNOR-91392 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 19188143 | SIGNOR-183640 |
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-91045 |
| AKT | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-244365 |
| AKT1 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-235515 |
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12172553 | SIGNOR-91392 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-183640 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91045 |
| AKT | phosphorylation → down-regulates activity | TSC2 | SIGNOR-244365 |
| AKT1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-235515 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91392 |
