Entity Details

Name CyclinD/CDK4_Ser1452
ID P49815
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinD/CDK4TSC2Ser1452LPSSSPRsPSGLRPRphosphorylation
up-regulates activity		32294430SIGNOR-274100
CyclinD1/CDK6TSC2Ser1452LPSSSPRsPSGLRPRphosphorylation
up-regulates activity		32294430SIGNOR-274102
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinD/CDK4phosphorylation
up-regulates
→
TSC2
PSer1452		phosphorylation
up-regulates
→		TSC232294430SIGNOR-274100
CyclinD1/CDK6phosphorylation
up-regulates
→
TSC2
PSer1452		phosphorylation
up-regulates
→		TSC232294430SIGNOR-274102
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinD/CDK4phosphorylation
→
up-regulates activity 		TSC2SIGNOR-274100
CyclinD1/CDK6phosphorylation
→
up-regulates activity 		TSC2SIGNOR-274102