Entity Details

Name MAPK1_Ser540
ID P49815
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK1TSC2Ser540KVMARSLsPPPELEEphosphorylation
down-regulates activity		15851026SIGNOR-249454
MAPK3TSC2Ser540KVMARSLsPPPELEEphosphorylation
down-regulates activity		15851026SIGNOR-249458
ERK1/2TSC2Ser540KVMARSLsPPPELEEphosphorylation
down-regulates activity		15851026SIGNOR-249455
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK1phosphorylation
up-regulates
→
TSC2
PSer540		phosphorylation
down-regulates
⊣		TSC215851026SIGNOR-249454
MAPK3phosphorylation
up-regulates
→
TSC2
PSer540		phosphorylation
down-regulates
⊣		TSC215851026SIGNOR-249458
ERK1/2phosphorylation
up-regulates
→
TSC2
PSer540		phosphorylation
down-regulates
⊣		TSC215851026SIGNOR-249455
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK1phosphorylation
→
down-regulates activity 		TSC2SIGNOR-249454
MAPK3phosphorylation
→
down-regulates activity 		TSC2SIGNOR-249458
ERK1/2phosphorylation
→
down-regulates activity 		TSC2SIGNOR-249455