| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | TSC2 | Ser1798 | GQRKRLIsSVEDFTE | phosphorylation down-regulates | 15342917 | SIGNOR-128634 |
| RPS6K | TSC2 | Ser1798 | GQRKRLIsSVEDFTE | phosphorylation down-regulates | 15342917 | SIGNOR-252801 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | phosphorylation up-regulates → | TSC2 PSer1798 | phosphorylation down-regulates ⊣ | TSC2 | 15342917 | SIGNOR-128634 |
| RPS6K | phosphorylation up-regulates → | TSC2 PSer1798 | phosphorylation down-regulates ⊣ | TSC2 | 15342917 | SIGNOR-252801 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA1 | phosphorylation![]() down-regulates | TSC2 | SIGNOR-128634 |
| RPS6K | phosphorylation![]() down-regulates | TSC2 | SIGNOR-252801 |