Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT1	TSC2	Ser939 View in OncoXplorer	SFRARSTsLNERPKS	phosphorylation down-regulates activity	12150915	SIGNOR-235511
AKT2	TSC2	Ser939 View in OncoXplorer	SFRARSTsLNERPKS	phosphorylation down-regulates	12172553	SIGNOR-91388
AKT2	TSC2	Ser939 View in OncoXplorer	SFRARSTsLNERPKS	phosphorylation down-regulates	19188143	SIGNOR-183636
AKT2	TSC2	Ser939 View in OncoXplorer	SFRARSTsLNERPKS	phosphorylation down-regulates	12150915	SIGNOR-91041
PRKCD	TSC2	Ser939 View in OncoXplorer	SFRARSTsLNERPKS	phosphorylation down-regulates activity	30684133	SIGNOR-277427
AKT	TSC2	Ser939 View in OncoXplorer	SFRARSTsLNERPKS	phosphorylation down-regulates activity	12150915	SIGNOR-244369

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT1	phosphorylation up-regulates →	TSC2 PSer939	phosphorylation down-regulates ⊣	TSC2	12150915	SIGNOR-235511
AKT2	phosphorylation up-regulates →	TSC2 PSer939	phosphorylation down-regulates ⊣	TSC2	12172553	SIGNOR-91388
AKT2	phosphorylation up-regulates →	TSC2 PSer939	phosphorylation down-regulates ⊣	TSC2	19188143	SIGNOR-183636
AKT2	phosphorylation up-regulates →	TSC2 PSer939	phosphorylation down-regulates ⊣	TSC2	12150915	SIGNOR-91041
PRKCD	phosphorylation up-regulates →	TSC2 PSer939	phosphorylation down-regulates ⊣	TSC2	30684133	SIGNOR-277427
AKT	phosphorylation up-regulates →	TSC2 PSer939	phosphorylation down-regulates ⊣	TSC2	12150915	SIGNOR-244369

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT1	phosphorylation → down-regulates activity	TSC2	SIGNOR-235511
AKT2	phosphorylation down-regulates	TSC2	SIGNOR-91388
AKT2	phosphorylation down-regulates	TSC2	SIGNOR-183636
AKT2	phosphorylation down-regulates	TSC2	SIGNOR-91041
PRKCD	phosphorylation → down-regulates activity	TSC2	SIGNOR-277427
AKT	phosphorylation → down-regulates activity	TSC2	SIGNOR-244369