| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11035810 | SIGNOR-83217 |
| AKT1 | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11035810 | SIGNOR-252589 |
| PRKCA | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11884598 | SIGNOR-115714 |
| PRKACA | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11035810 | SIGNOR-83221 |
| PRKCB | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11884598 | SIGNOR-115718 |
| PRKCD | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11884598 | SIGNOR-115722 |
| CAMK2B | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 20841359 | SIGNOR-167962 |
| SGK3 | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates activity | 16543730 | SIGNOR-249165 |
| RPS6KA3 | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates activity | 11583116 | SIGNOR-110827 |
| PRKCG | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11884598 | SIGNOR-115726 |
| PRKCH | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 11884598 | SIGNOR-115730 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11035810 | SIGNOR-83217 |
| AKT1 | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11035810 | SIGNOR-252589 |
| PRKCA | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11884598 | SIGNOR-115714 |
| PRKACA | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11035810 | SIGNOR-83221 |
| PRKCB | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11884598 | SIGNOR-115718 |
| PRKCD | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11884598 | SIGNOR-115722 |
| CAMK2B | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 20841359 | SIGNOR-167962 |
| SGK3 | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 16543730 | SIGNOR-249165 |
| RPS6KA3 | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11583116 | SIGNOR-110827 |
| PRKCG | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11884598 | SIGNOR-115726 |
| PRKCH | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 11884598 | SIGNOR-115730 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation down-regulates | GSK3A | SIGNOR-83217 |
| AKT1 | phosphorylation down-regulates | GSK3A | SIGNOR-252589 |
| PRKCA | phosphorylation down-regulates | GSK3A | SIGNOR-115714 |
| PRKACA | phosphorylation down-regulates | GSK3A | SIGNOR-83221 |
| PRKCB | phosphorylation down-regulates | GSK3A | SIGNOR-115718 |
| PRKCD | phosphorylation down-regulates | GSK3A | SIGNOR-115722 |
| CAMK2B | phosphorylation down-regulates | GSK3A | SIGNOR-167962 |
| SGK3 | phosphorylation → down-regulates activity | GSK3A | SIGNOR-249165 |
| RPS6KA3 | phosphorylation → down-regulates activity | GSK3A | SIGNOR-110827 |
| PRKCG | phosphorylation down-regulates | GSK3A | SIGNOR-115726 |
| PRKCH | phosphorylation down-regulates | GSK3A | SIGNOR-115730 |
