| Name | GSK3B |
| ID | P49841 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 56-340 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 28646232 | SIGNOR-262524 |
| MAPK14 | GSK3B | Ser389 | ARIQAAAsTPTNATA | phosphorylation down-regulates | 18451303 | SIGNOR-178603 |
| MAPK14 | GSK3B | Ser389 | ARIQAAAsTPTNATA | phosphorylation down-regulates | 17726008 | SIGNOR-157548 |
| RPS6KA1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 11584304 | SIGNOR-110917 |
| PP2Ca_R1A_Bd | GSK3B | Ser9 | SGRPRTTsFAESCKP | dephosphorylation up-regulates activity | 20080667 | SIGNOR-254754 |
| MAPK1 | GSK3B | Thr43 | KVTTVVAtPGQGPDR | phosphorylation down-regulates | 16039586 | SIGNOR-138894 |
| GSK3B | GSK3B | Tyr216 | RGEPNVSyICSRYYR | phosphorylation up-regulates activity | 14570592 | SIGNOR-236564 |
| AKT | GSK3B | – | phosphorylation down-regulates | 28712664 | SIGNOR-255488 | |
| ALK | GSK3B | – | phosphorylation up-regulates activity | 33479180 | SIGNOR-280180 | |
| MAP2K1 | GSK3B | Tyr216 | RGEPNVSyICSRYYR | phosphorylation up-regulates activity | 15020233 | SIGNOR-236622 |
| SGK3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 16543730 | SIGNOR-249167 |
| AURKA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 19060929 | SIGNOR-279357 |
| AKT3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245424 |
| AKT1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245416 |
| ERK1/2 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 28646232 | SIGNOR-262522 |
| PRKCH | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 19836308 | SIGNOR-188585 |
| AKT1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 9373175 | SIGNOR-252546 |
| PRKG2 | GSK3B | – | phosphorylation down-regulates activity | 18551195 | SIGNOR-280095 | |
| PRKCD | GSK3B | – | phosphorylation down-regulates activity | 29903018 | SIGNOR-280084 | |
| STK11 | GSK3B | – | phosphorylation down-regulates activity | 21272562 | SIGNOR-280148 | |
| PTK2 | GSK3B | – | phosphorylation up-regulates activity | 25472995 | SIGNOR-278986 | |
| PASK | GSK3B | – | phosphorylation down-regulates activity | 23853095 | SIGNOR-279639 | |
| RPS6KA6 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 32396532 | SIGNOR-275801 |
| PRKG1 | GSK3B | – | phosphorylation down-regulates activity | 22131966 | SIGNOR-280094 | |
| MEK1/2 | GSK3B | Tyr216 | RGEPNVSyICSRYYR | phosphorylation up-regulates activity | 15020233 | SIGNOR-244780 |
| MAPK3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 28646232 | SIGNOR-262523 |
| PRKACA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 19836308 | SIGNOR-188577 |
| MAPK3 | GSK3B | Thr43 | KVTTVVAtPGQGPDR | phosphorylation down-regulates | 16039586 | SIGNOR-138898 |
| AKT2 | GSK3B | – | phosphorylation down-regulates activity | 16293724 | SIGNOR-235718 | |
| PKA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 26088133 | SIGNOR-264819 |
| PRKCE | GSK3B | – | phosphorylation down-regulates activity | 21660969 | SIGNOR-279101 | |
| GSK3B | GSK3B | Tyr216 | RGEPNVSyICSRYYR | phosphorylation up-regulates activity | 20331603 | SIGNOR-217865 |
| MAP4K5 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 16914735 | SIGNOR-148908 |
| RPS6K | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 11584304 | SIGNOR-252788 |
| PRKCA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 19836308 | SIGNOR-188581 |
| PRKCZ | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 14657655 | SIGNOR-119889 |
| AKT | GSK3B | – | phosphorylation down-regulates activity | 16293724 | SIGNOR-278095 | |
| EPM2A | GSK3B | Ser9 | SGRPRTTsFAESCKP | dephosphorylation unknown | 16959610 | SIGNOR-248345 |
| AKT2 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245420 |
| CAMK4 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 32531122 | SIGNOR-279142 |
| PIK3CB | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23504389 | SIGNOR-279089 |
| Gbeta | GSK3B | – | phosphorylation down-regulates | 16039586 | SIGNOR-270059 | |
| AKT | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245428 |
| AKT | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 9373175 | SIGNOR-242578 |
| SGK3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 12054501 | SIGNOR-249166 |
| MET | GSK3B | Tyr56 | DRPQEVSyTDTKVIG | phosphorylation up-regulates activity | 30711629 | SIGNOR-277428 |
| ILK | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 27683053 | SIGNOR-278252 |
| PP1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | dephosphorylation up-regulates activity | 26088133 | SIGNOR-264820 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 28646232 | SIGNOR-262524 |
| MAPK14 | phosphorylation up-regulates → | GSK3B PSer389 | phosphorylation down-regulates ⊣ | GSK3B | 18451303 | SIGNOR-178603 |
| MAPK14 | phosphorylation up-regulates → | GSK3B PSer389 | phosphorylation down-regulates ⊣ | GSK3B | 17726008 | SIGNOR-157548 |
| RPS6KA1 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 11584304 | SIGNOR-110917 |
| PP2Ca_R1A_Bd | dephosphorylation down-regulates ⊣ | GSK3B PSer9 | dephosphorylation down-regulates ⊣ | GSK3B | 20080667 | SIGNOR-254754 |
| MAPK1 | phosphorylation up-regulates → | GSK3B PThr43 | phosphorylation down-regulates ⊣ | GSK3B | 16039586 | SIGNOR-138894 |
| GSK3B | phosphorylation up-regulates → | GSK3B PTyr216 | phosphorylation up-regulates → | GSK3B | 14570592 | SIGNOR-236564 |
| MAP2K1 | phosphorylation up-regulates → | GSK3B PTyr216 | phosphorylation up-regulates → | GSK3B | 15020233 | SIGNOR-236622 |
| SGK3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 16543730 | SIGNOR-249167 |
| AURKA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19060929 | SIGNOR-279357 |
| AKT3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245424 |
| AKT1 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245416 |
| ERK1/2 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 28646232 | SIGNOR-262522 |
| PRKCH | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19836308 | SIGNOR-188585 |
| AKT1 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 9373175 | SIGNOR-252546 |
| RPS6KA6 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 32396532 | SIGNOR-275801 |
| MEK1/2 | phosphorylation up-regulates → | GSK3B PTyr216 | phosphorylation up-regulates → | GSK3B | 15020233 | SIGNOR-244780 |
| MAPK3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 28646232 | SIGNOR-262523 |
| PRKACA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19836308 | SIGNOR-188577 |
| MAPK3 | phosphorylation up-regulates → | GSK3B PThr43 | phosphorylation down-regulates ⊣ | GSK3B | 16039586 | SIGNOR-138898 |
| PKA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 26088133 | SIGNOR-264819 |
| GSK3B | phosphorylation up-regulates → | GSK3B PTyr216 | phosphorylation up-regulates → | GSK3B | 20331603 | SIGNOR-217865 |
| MAP4K5 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 16914735 | SIGNOR-148908 |
| RPS6K | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 11584304 | SIGNOR-252788 |
| PRKCA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19836308 | SIGNOR-188581 |
| PRKCZ | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 14657655 | SIGNOR-119889 |
| EPM2A | dephosphorylation down-regulates ⊣ | GSK3B PSer9 | dephosphorylation up-regulates → | GSK3B | 16959610 | SIGNOR-248345 |
| AKT2 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245420 |
| CAMK4 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 32531122 | SIGNOR-279142 |
| PIK3CB | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23504389 | SIGNOR-279089 |
| AKT | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245428 |
| AKT | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 9373175 | SIGNOR-242578 |
| SGK3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 12054501 | SIGNOR-249166 |
| MET | phosphorylation up-regulates → | GSK3B PTyr56 | phosphorylation up-regulates → | GSK3B | 30711629 | SIGNOR-277428 |
| ILK | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 27683053 | SIGNOR-278252 |
| PP1 | dephosphorylation down-regulates ⊣ | GSK3B PSer9 | dephosphorylation down-regulates ⊣ | GSK3B | 26088133 | SIGNOR-264820 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-262524 |
| MAPK14 | phosphorylation down-regulates | GSK3B | SIGNOR-178603 |
| MAPK14 | phosphorylation down-regulates | GSK3B | SIGNOR-157548 |
| RPS6KA1 | phosphorylation down-regulates | GSK3B | SIGNOR-110917 |
| PP2Ca_R1A_Bd | dephosphorylation → up-regulates activity | GSK3B | SIGNOR-254754 |
| MAPK1 | phosphorylation down-regulates | GSK3B | SIGNOR-138894 |
| GSK3B | phosphorylation → up-regulates activity | GSK3B | SIGNOR-236564 |
| AKT | phosphorylation down-regulates | GSK3B | SIGNOR-255488 |
| ALK | phosphorylation → up-regulates activity | GSK3B | SIGNOR-280180 |
| MAP2K1 | phosphorylation → up-regulates activity | GSK3B | SIGNOR-236622 |
| SGK3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-249167 |
| AURKA | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279357 |
| AKT3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245424 |
| AKT1 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245416 |
| ERK1/2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-262522 |
| PRKCH | phosphorylation down-regulates | GSK3B | SIGNOR-188585 |
| AKT1 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-252546 |
| PRKG2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-280095 |
| PRKCD | phosphorylation → down-regulates activity | GSK3B | SIGNOR-280084 |
| STK11 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-280148 |
| PTK2 | phosphorylation → up-regulates activity | GSK3B | SIGNOR-278986 |
| PASK | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279639 |
| RPS6KA6 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-275801 |
| PRKG1 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-280094 |
| MEK1/2 | phosphorylation → up-regulates activity | GSK3B | SIGNOR-244780 |
| MAPK3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-262523 |
| PRKACA | phosphorylation → down-regulates activity | GSK3B | SIGNOR-188577 |
| MAPK3 | phosphorylation down-regulates | GSK3B | SIGNOR-138898 |
| AKT2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-235718 |
| PKA | phosphorylation → down-regulates activity | GSK3B | SIGNOR-264819 |
| PRKCE | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279101 |
| GSK3B | phosphorylation → up-regulates activity | GSK3B | SIGNOR-217865 |
| MAP4K5 | phosphorylation down-regulates | GSK3B | SIGNOR-148908 |
| RPS6K | phosphorylation down-regulates | GSK3B | SIGNOR-252788 |
| PRKCA | phosphorylation down-regulates | GSK3B | SIGNOR-188581 |
| PRKCZ | phosphorylation down-regulates | GSK3B | SIGNOR-119889 |
| AKT | phosphorylation → down-regulates activity | GSK3B | SIGNOR-278095 |
| EPM2A | dephosphorylation → unknown | GSK3B | SIGNOR-248345 |
| AKT2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245420 |
| CAMK4 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279142 |
| PIK3CB | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279089 |
| Gbeta | phosphorylation down-regulates | GSK3B | SIGNOR-270059 |
| AKT | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245428 |
| AKT | phosphorylation → down-regulates activity | GSK3B | SIGNOR-242578 |
| SGK3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-249166 |
| MET | phosphorylation → up-regulates activity | GSK3B | SIGNOR-277428 |
| ILK | phosphorylation → down-regulates activity | GSK3B | SIGNOR-278252 |
| PP1 | dephosphorylation → up-regulates activity | GSK3B | SIGNOR-264820 |