| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 16543730 | SIGNOR-249167 |
| MAPK1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 28646232 | SIGNOR-262524 |
| SGK3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 12054501 | SIGNOR-249166 |
| EPM2A | GSK3B | Ser9 | SGRPRTTsFAESCKP | dephosphorylation unknown | 16959610 | SIGNOR-248345 |
| ILK | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 27683053 | SIGNOR-278252 |
| AKT2 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245420 |
| AKT | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245428 |
| PRKCA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 19836308 | SIGNOR-188581 |
| PP2Ca_R1A_Bd | GSK3B | Ser9 | SGRPRTTsFAESCKP | dephosphorylation up-regulates activity | 20080667 | SIGNOR-254754 |
| AKT3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245424 |
| ERK1/2 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 28646232 | SIGNOR-262522 |
| MAP4K5 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 16914735 | SIGNOR-148908 |
| AKT | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 9373175 | SIGNOR-242578 |
| PKA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 26088133 | SIGNOR-264819 |
| PP1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | dephosphorylation up-regulates activity | 26088133 | SIGNOR-264820 |
| PRKCZ | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 14657655 | SIGNOR-119889 |
| AKT1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245416 |
| RPS6KA1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 11584304 | SIGNOR-110917 |
| RPS6K | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 11584304 | SIGNOR-252788 |
| PRKCH | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates | 19836308 | SIGNOR-188585 |
| MAPK3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 28646232 | SIGNOR-262523 |
| AKT1 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 9373175 | SIGNOR-252546 |
| RPS6KA6 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 32396532 | SIGNOR-275801 |
| PIK3CB | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23504389 | SIGNOR-279089 |
| PRKACA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 19836308 | SIGNOR-188577 |
| CAMK4 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 32531122 | SIGNOR-279142 |
| AURKA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 19060929 | SIGNOR-279357 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 16543730 | SIGNOR-249167 |
| MAPK1 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 28646232 | SIGNOR-262524 |
| SGK3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 12054501 | SIGNOR-249166 |
| EPM2A | dephosphorylation down-regulates ⊣ | GSK3B PSer9 | dephosphorylation up-regulates → | GSK3B | 16959610 | SIGNOR-248345 |
| ILK | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 27683053 | SIGNOR-278252 |
| AKT2 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245420 |
| AKT | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245428 |
| PRKCA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19836308 | SIGNOR-188581 |
| PP2Ca_R1A_Bd | dephosphorylation down-regulates ⊣ | GSK3B PSer9 | dephosphorylation down-regulates ⊣ | GSK3B | 20080667 | SIGNOR-254754 |
| AKT3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245424 |
| ERK1/2 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 28646232 | SIGNOR-262522 |
| MAP4K5 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 16914735 | SIGNOR-148908 |
| AKT | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 9373175 | SIGNOR-242578 |
| PKA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 26088133 | SIGNOR-264819 |
| PP1 | dephosphorylation down-regulates ⊣ | GSK3B PSer9 | dephosphorylation down-regulates ⊣ | GSK3B | 26088133 | SIGNOR-264820 |
| PRKCZ | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 14657655 | SIGNOR-119889 |
| AKT1 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245416 |
| RPS6KA1 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 11584304 | SIGNOR-110917 |
| RPS6K | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 11584304 | SIGNOR-252788 |
| PRKCH | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19836308 | SIGNOR-188585 |
| MAPK3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 28646232 | SIGNOR-262523 |
| AKT1 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 9373175 | SIGNOR-252546 |
| RPS6KA6 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 32396532 | SIGNOR-275801 |
| PIK3CB | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23504389 | SIGNOR-279089 |
| PRKACA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19836308 | SIGNOR-188577 |
| CAMK4 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 32531122 | SIGNOR-279142 |
| AURKA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19060929 | SIGNOR-279357 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-249167 |
| MAPK1 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-262524 |
| SGK3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-249166 |
| EPM2A | dephosphorylation → unknown | GSK3B | SIGNOR-248345 |
| ILK | phosphorylation → down-regulates activity | GSK3B | SIGNOR-278252 |
| AKT2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245420 |
| AKT | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245428 |
| PRKCA | phosphorylation down-regulates | GSK3B | SIGNOR-188581 |
| PP2Ca_R1A_Bd | dephosphorylation → up-regulates activity | GSK3B | SIGNOR-254754 |
| AKT3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245424 |
| ERK1/2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-262522 |
| MAP4K5 | phosphorylation down-regulates | GSK3B | SIGNOR-148908 |
| AKT | phosphorylation → down-regulates activity | GSK3B | SIGNOR-242578 |
| PKA | phosphorylation → down-regulates activity | GSK3B | SIGNOR-264819 |
| PP1 | dephosphorylation → up-regulates activity | GSK3B | SIGNOR-264820 |
| PRKCZ | phosphorylation down-regulates | GSK3B | SIGNOR-119889 |
| AKT1 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245416 |
| RPS6KA1 | phosphorylation down-regulates | GSK3B | SIGNOR-110917 |
| RPS6K | phosphorylation down-regulates | GSK3B | SIGNOR-252788 |
| PRKCH | phosphorylation down-regulates | GSK3B | SIGNOR-188585 |
| MAPK3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-262523 |
| AKT1 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-252546 |
| RPS6KA6 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-275801 |
| PIK3CB | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279089 |
| PRKACA | phosphorylation → down-regulates activity | GSK3B | SIGNOR-188577 |
| CAMK4 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279142 |
| AURKA | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279357 |
