Entity Details

Name MAP2K1_Tyr216
ID P49841
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BGSK3BTyr216RGEPNVSyICSRYYRphosphorylation
up-regulates activity		20331603SIGNOR-217865
MAP2K1GSK3BTyr216RGEPNVSyICSRYYRphosphorylation
up-regulates activity		15020233SIGNOR-236622
MEK1/2GSK3BTyr216RGEPNVSyICSRYYRphosphorylation
up-regulates activity		15020233SIGNOR-244780
GSK3BGSK3BTyr216RGEPNVSyICSRYYRphosphorylation
up-regulates activity		14570592SIGNOR-236564
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
GSK3B
PTyr216		phosphorylation
up-regulates
→		GSK3B20331603SIGNOR-217865
MAP2K1phosphorylation
up-regulates
→
GSK3B
PTyr216		phosphorylation
up-regulates
→		GSK3B15020233SIGNOR-236622
MEK1/2phosphorylation
up-regulates
→
GSK3B
PTyr216		phosphorylation
up-regulates
→		GSK3B15020233SIGNOR-244780
GSK3Bphosphorylation
up-regulates
→
GSK3B
PTyr216		phosphorylation
up-regulates
→		GSK3B14570592SIGNOR-236564
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
→
up-regulates activity 		GSK3BSIGNOR-217865
MAP2K1phosphorylation
→
up-regulates activity 		GSK3BSIGNOR-236622
MEK1/2phosphorylation
→
up-regulates activity 		GSK3BSIGNOR-244780
GSK3Bphosphorylation
→
up-regulates activity 		GSK3BSIGNOR-236564