| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | GSK3B | Thr43 | KVTTVVAtPGQGPDR | phosphorylation down-regulates | 16039586 | SIGNOR-138894 |
| MAPK3 | GSK3B | Thr43 | KVTTVVAtPGQGPDR | phosphorylation down-regulates | 16039586 | SIGNOR-138898 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | GSK3B PThr43 | phosphorylation down-regulates ⊣ | GSK3B | 16039586 | SIGNOR-138894 |
| MAPK3 | phosphorylation up-regulates → | GSK3B PThr43 | phosphorylation down-regulates ⊣ | GSK3B | 16039586 | SIGNOR-138898 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation![]() down-regulates | GSK3B | SIGNOR-138894 |
| MAPK3 | phosphorylation![]() down-regulates | GSK3B | SIGNOR-138898 |