Entity Details

Name MRE11
ID P49959
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ATMMRE11Ser264EQQLFYIsQPGSSVVphosphorylation
up-regulates		10608806SIGNOR-73366
RPS6KB1MRE11Thr597SQRGRADtGLETSTRphosphorylation
down-regulates quantity by destabilization		28967905SIGNOR-265944
CSNK2A1MRE11Ser689
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KGVDFESsEDDDDDPphosphorylation
up-regulates activity		28436950SIGNOR-265895
PLK1MRE11Ser649
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EVIEVDEsDVEEDIFphosphorylation
down-regulates activity		28512243SIGNOR-265943
RPS6KA2MRE11Ser676
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TSSSKIMsQSQVSKGphosphorylation
down-regulates activity		24297933SIGNOR-280116
CSNK2A1MRE11Ser688
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SKGVDFEsSEDDDDDphosphorylation
up-regulates activity		28436950SIGNOR-265893
CSNK2A1MRE11Ser558
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AEQMANDsDDSISAAphosphorylation
up-regulates activity		28436950SIGNOR-265896
CSNK2A1MRE11Ser561MANDSDDsISAATNKphosphorylation
up-regulates activity		28436950SIGNOR-265894
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ATMphosphorylation
up-regulates
→
MRE11
PSer264		phosphorylation
up-regulates
→		MRE1110608806SIGNOR-73366
RPS6KB1phosphorylation
up-regulates
→
MRE11
PThr597		phosphorylation
down-regulates
⊣		MRE1128967905SIGNOR-265944
CSNK2A1phosphorylation
up-regulates
→
MRE11
PSer689		phosphorylation
up-regulates
→		MRE1128436950SIGNOR-265895
PLK1phosphorylation
up-regulates
→
MRE11
PSer649		phosphorylation
down-regulates
⊣		MRE1128512243SIGNOR-265943
RPS6KA2phosphorylation
up-regulates
→
MRE11
PSer676		phosphorylation
down-regulates
⊣		MRE1124297933SIGNOR-280116
CSNK2A1phosphorylation
up-regulates
→
MRE11
PSer688		phosphorylation
up-regulates
→		MRE1128436950SIGNOR-265893
CSNK2A1phosphorylation
up-regulates
→
MRE11
PSer558		phosphorylation
up-regulates
→		MRE1128436950SIGNOR-265896
CSNK2A1phosphorylation
up-regulates
→
MRE11
PSer561		phosphorylation
up-regulates
→		MRE1128436950SIGNOR-265894
Regulator Mechanism/Effect Target SIGNOR-ID
ATMphosphorylation
→
up-regulates 		MRE11SIGNOR-73366
RPS6KB1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MRE11SIGNOR-265944
CSNK2A1phosphorylation
→
up-regulates activity 		MRE11SIGNOR-265895
PLK1phosphorylation
→
down-regulates activity 		MRE11SIGNOR-265943
RPS6KA2phosphorylation
→
down-regulates activity 		MRE11SIGNOR-280116
CSNK2A1phosphorylation
→
up-regulates activity 		MRE11SIGNOR-265893
CSNK2A1phosphorylation
→
up-regulates activity 		MRE11SIGNOR-265896
CSNK2A1phosphorylation
→
up-regulates activity 		MRE11SIGNOR-265894