| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | MRE11 | Ser649 | EVIEVDEsDVEEDIF | phosphorylation down-regulates activity | 28512243 | SIGNOR-265943 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | MRE11 PSer649 | phosphorylation down-regulates ⊣ | MRE11 | 28512243 | SIGNOR-265943 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → down-regulates activity | MRE11 | SIGNOR-265943 |
