| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | TOB1 | Ser154 | SSVSSSPsPPFGHSA | phosphorylation down-regulates | 12151396 | SIGNOR-91071 |
| MAPK3 | TOB1 | Ser164 | FGHSAAVsPTFMPRS | phosphorylation down-regulates | 12050114 | SIGNOR-88736 |
| MAPK3 | TOB1 | Ser152 | PASSVSSsPSPPFGH | phosphorylation down-regulates | 12050114 | SIGNOR-88728 |
| MAPK1 | TOB1 | Ser164 | FGHSAAVsPTFMPRS | phosphorylation down-regulates | 12050114 | SIGNOR-88724 |
| Gbeta | TOB1 | – | phosphorylation down-regulates | 12050114 | SIGNOR-270123 | |
| MAPK3 | TOB1 | Ser154 | SSVSSSPsPPFGHSA | phosphorylation down-regulates | 12151396 | SIGNOR-91059 |
| MAPK9 | TOB1 | Ser164 | FGHSAAVsPTFMPRS | phosphorylation down-regulates | 12151396 | SIGNOR-91075 |
| MAPK3 | TOB1 | Ser154 | SSVSSSPsPPFGHSA | phosphorylation down-regulates | 12050114 | SIGNOR-88732 |
| MAPK3 | TOB1 | Ser164 | FGHSAAVsPTFMPRS | phosphorylation down-regulates | 12151396 | SIGNOR-91063 |
| MAPK1 | TOB1 | Ser154 | SSVSSSPsPPFGHSA | phosphorylation down-regulates | 12050114 | SIGNOR-88720 |
| MAPK9 | TOB1 | Ser152 | PASSVSSsPSPPFGH | phosphorylation down-regulates | 12151396 | SIGNOR-91067 |
| ERK1/2 | TOB1 | – | phosphorylation down-regulates | 12050114 | SIGNOR-270210 | |
| MAPK9 | TOB1 | Ser154 | SSVSSSPsPPFGHSA | phosphorylation down-regulates | 12050114 | SIGNOR-88744 |
| MAPK9 | TOB1 | Ser164 | FGHSAAVsPTFMPRS | phosphorylation down-regulates | 12050114 | SIGNOR-88748 |
| MAPK1 | TOB1 | Ser152 | PASSVSSsPSPPFGH | phosphorylation down-regulates | 12050114 | SIGNOR-88716 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | phosphorylation up-regulates → | TOB1 PSer154 | phosphorylation down-regulates ⊣ | TOB1 | 12151396 | SIGNOR-91071 |
| MAPK3 | phosphorylation up-regulates → | TOB1 PSer164 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88736 |
| MAPK3 | phosphorylation up-regulates → | TOB1 PSer152 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88728 |
| MAPK1 | phosphorylation up-regulates → | TOB1 PSer164 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88724 |
| MAPK3 | phosphorylation up-regulates → | TOB1 PSer154 | phosphorylation down-regulates ⊣ | TOB1 | 12151396 | SIGNOR-91059 |
| MAPK9 | phosphorylation up-regulates → | TOB1 PSer164 | phosphorylation down-regulates ⊣ | TOB1 | 12151396 | SIGNOR-91075 |
| MAPK3 | phosphorylation up-regulates → | TOB1 PSer154 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88732 |
| MAPK3 | phosphorylation up-regulates → | TOB1 PSer164 | phosphorylation down-regulates ⊣ | TOB1 | 12151396 | SIGNOR-91063 |
| MAPK1 | phosphorylation up-regulates → | TOB1 PSer154 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88720 |
| MAPK9 | phosphorylation up-regulates → | TOB1 PSer152 | phosphorylation down-regulates ⊣ | TOB1 | 12151396 | SIGNOR-91067 |
| MAPK9 | phosphorylation up-regulates → | TOB1 PSer154 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88744 |
| MAPK9 | phosphorylation up-regulates → | TOB1 PSer164 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88748 |
| MAPK1 | phosphorylation up-regulates → | TOB1 PSer152 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88716 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK9 | phosphorylation down-regulates | TOB1 | SIGNOR-91071 |
| MAPK3 | phosphorylation down-regulates | TOB1 | SIGNOR-88736 |
| MAPK3 | phosphorylation down-regulates | TOB1 | SIGNOR-88728 |
| MAPK1 | phosphorylation down-regulates | TOB1 | SIGNOR-88724 |
| Gbeta | phosphorylation down-regulates | TOB1 | SIGNOR-270123 |
| MAPK3 | phosphorylation down-regulates | TOB1 | SIGNOR-91059 |
| MAPK9 | phosphorylation down-regulates | TOB1 | SIGNOR-91075 |
| MAPK3 | phosphorylation down-regulates | TOB1 | SIGNOR-88732 |
| MAPK3 | phosphorylation down-regulates | TOB1 | SIGNOR-91063 |
| MAPK1 | phosphorylation down-regulates | TOB1 | SIGNOR-88720 |
| MAPK9 | phosphorylation down-regulates | TOB1 | SIGNOR-91067 |
| ERK1/2 | phosphorylation down-regulates | TOB1 | SIGNOR-270210 |
| MAPK9 | phosphorylation down-regulates | TOB1 | SIGNOR-88744 |
| MAPK9 | phosphorylation down-regulates | TOB1 | SIGNOR-88748 |
| MAPK1 | phosphorylation down-regulates | TOB1 | SIGNOR-88716 |
