| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | TOB1 | Ser152 | PASSVSSsPSPPFGH | phosphorylation down-regulates | 12050114 | SIGNOR-88716 |
| MAPK3 | TOB1 | Ser152 | PASSVSSsPSPPFGH | phosphorylation down-regulates | 12050114 | SIGNOR-88728 |
| MAPK9 | TOB1 | Ser152 | PASSVSSsPSPPFGH | phosphorylation down-regulates | 12151396 | SIGNOR-91067 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | TOB1 PSer152 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88716 |
| MAPK3 | phosphorylation up-regulates → | TOB1 PSer152 | phosphorylation down-regulates ⊣ | TOB1 | 12050114 | SIGNOR-88728 |
| MAPK9 | phosphorylation up-regulates → | TOB1 PSer152 | phosphorylation down-regulates ⊣ | TOB1 | 12151396 | SIGNOR-91067 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation down-regulates | TOB1 | SIGNOR-88716 |
| MAPK3 | phosphorylation down-regulates | TOB1 | SIGNOR-88728 |
| MAPK9 | phosphorylation down-regulates | TOB1 | SIGNOR-91067 |
