| Name | CDK9 |
| ID | P50750 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 19-315 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation down-regulates activity | 18829461 | SIGNOR-248490 |
| PP1 | CDK9 | Ser175 | FGLARAFsLAKNSQP | dephosphorylation up-regulates | 21533037 | SIGNOR-264671 |
| PPM1B | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation unknown | 18829461 | SIGNOR-181396 |
| CDK7 | CDK9 | Thr186 | NSQPNRYtNRVVTLW | phosphorylation up-regulates activity | 23064645 | SIGNOR-279455 |
| ALK | CDK9 | Tyr19 | FCDEVSKyEKLAKIG | phosphorylation up-regulates activity | 36253486 | SIGNOR-277607 |
| PPP1CC | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation up-regulates | 21533037 | SIGNOR-173454 |
| PPP1CC | CDK9 | Ser175 | FGLARAFsLAKNSQP | dephosphorylation up-regulates | 21533037 | SIGNOR-173450 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation up-regulates → | CDK9 | 18829461 | SIGNOR-248490 |
| PP1 | dephosphorylation down-regulates ⊣ | CDK9 PSer175 | dephosphorylation down-regulates ⊣ | CDK9 | 21533037 | SIGNOR-264671 |
| PPM1B | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation up-regulates → | CDK9 | 18829461 | SIGNOR-181396 |
| CDK7 | phosphorylation up-regulates → | CDK9 PThr186 | phosphorylation up-regulates → | CDK9 | 23064645 | SIGNOR-279455 |
| ALK | phosphorylation up-regulates → | CDK9 PTyr19 | phosphorylation up-regulates → | CDK9 | 36253486 | SIGNOR-277607 |
| PPP1CC | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation down-regulates ⊣ | CDK9 | 21533037 | SIGNOR-173454 |
| PPP1CC | dephosphorylation down-regulates ⊣ | CDK9 PSer175 | dephosphorylation down-regulates ⊣ | CDK9 | 21533037 | SIGNOR-173450 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1A | dephosphorylation → down-regulates activity | CDK9 | SIGNOR-248490 |
| PP1 | dephosphorylation → up-regulates | CDK9 | SIGNOR-264671 |
| PPM1B | dephosphorylation → unknown | CDK9 | SIGNOR-181396 |
| CDK7 | phosphorylation → up-regulates activity | CDK9 | SIGNOR-279455 |
| ALK | phosphorylation → up-regulates activity | CDK9 | SIGNOR-277607 |
| PPP1CC | dephosphorylation → up-regulates | CDK9 | SIGNOR-173454 |
| PPP1CC | dephosphorylation → up-regulates | CDK9 | SIGNOR-173450 |