| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation down-regulates activity | 18829461 | SIGNOR-248490 |
| PPM1B | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation unknown | 18829461 | SIGNOR-181396 |
| CDK7 | CDK9 | Thr186 | NSQPNRYtNRVVTLW | phosphorylation up-regulates activity | 23064645 | SIGNOR-279455 |
| PPP1CC | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation up-regulates | 21533037 | SIGNOR-173454 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation up-regulates → | CDK9 | 18829461 | SIGNOR-248490 |
| PPM1B | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation up-regulates → | CDK9 | 18829461 | SIGNOR-181396 |
| CDK7 | phosphorylation up-regulates → | CDK9 PThr186 | phosphorylation up-regulates → | CDK9 | 23064645 | SIGNOR-279455 |
| PPP1CC | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation down-regulates ⊣ | CDK9 | 21533037 | SIGNOR-173454 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1A | dephosphorylation → down-regulates activity | CDK9 | SIGNOR-248490 |
| PPM1B | dephosphorylation → unknown | CDK9 | SIGNOR-181396 |
| CDK7 | phosphorylation → up-regulates activity | CDK9 | SIGNOR-279455 |
| PPP1CC | dephosphorylation → up-regulates | CDK9 | SIGNOR-173454 |
