Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTEN	RAB7A	Ser72 View in OncoXplorer	AGQERFQsLGVAFYR	dephosphorylation up-regulates activity	26869029	SIGNOR-276960
LRRK1	RAB7A	Ser72 View in OncoXplorer	AGQERFQsLGVAFYR	phosphorylation up-regulates activity	33459343	SIGNOR-278212
PTEN	RAB7A	Tyr183 View in OncoXplorer	QETEVELyNEFPEPI	dephosphorylation up-regulates activity	26869029	SIGNOR-276959

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTEN	dephosphorylation down-regulates ⊣	RAB7A PSer72	dephosphorylation down-regulates ⊣	RAB7A	26869029	SIGNOR-276960
LRRK1	phosphorylation up-regulates →	RAB7A PSer72	phosphorylation up-regulates →	RAB7A	33459343	SIGNOR-278212
PTEN	dephosphorylation down-regulates ⊣	RAB7A PTyr183	dephosphorylation down-regulates ⊣	RAB7A	26869029	SIGNOR-276959

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTEN	dephosphorylation → up-regulates activity	RAB7A	SIGNOR-276960
LRRK1	phosphorylation → up-regulates activity	RAB7A	SIGNOR-278212
PTEN	dephosphorylation → up-regulates activity	RAB7A	SIGNOR-276959