| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | RAB7A | Ser72 | AGQERFQsLGVAFYR | dephosphorylation up-regulates activity | 26869029 | SIGNOR-276960 |
| LRRK1 | RAB7A | Ser72 | AGQERFQsLGVAFYR | phosphorylation up-regulates activity | 33459343 | SIGNOR-278212 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | dephosphorylation down-regulates ⊣ | RAB7A PSer72 | dephosphorylation down-regulates ⊣ | RAB7A | 26869029 | SIGNOR-276960 |
| LRRK1 | phosphorylation up-regulates → | RAB7A PSer72 | phosphorylation up-regulates → | RAB7A | 33459343 | SIGNOR-278212 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTEN | dephosphorylation → up-regulates activity | RAB7A | SIGNOR-276960 |
| LRRK1 | phosphorylation → up-regulates activity | RAB7A | SIGNOR-278212 |
