| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | SCNN1B | Thr615 | QALPIPGtPPPNYDS | phosphorylation down-regulates quantity by destabilization | 11805112 | SIGNOR-249446 |
| MAPK3 | SCNN1B | Thr615 | QALPIPGtPPPNYDS | phosphorylation down-regulates quantity by destabilization | 11805112 | SIGNOR-249447 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | SCNN1B PThr615 | phosphorylation down-regulates ⊣ | SCNN1B | 11805112 | SIGNOR-249446 |
| MAPK3 | phosphorylation up-regulates → | SCNN1B PThr615 | phosphorylation down-regulates ⊣ | SCNN1B | 11805112 | SIGNOR-249447 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation![]() down-regulates quantity by destabilization | SCNN1B | SIGNOR-249446 |
| MAPK3 | phosphorylation![]() down-regulates quantity by destabilization | SCNN1B | SIGNOR-249447 |