| Name | BLK |
| ID | P51451 |
| Role | kinase |
| Enzymatic Domains |
SH3 58-118 PROSITE-ProRule
SH2 124-220 PROSITE-ProRule
Protein kinase 241-494 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BLK | SOCS1 | Tyr80 | LLDACGFyWGPLSVH | phosphorylation down-regulates activity | 31101761 | SIGNOR-277889 |
| BLK | FCGR2A | Tyr288 | YETADGGyMTLNPRA | phosphorylation up-regulates activity | 8756631 | SIGNOR-249311 |
| BLK | FCGR2A | Tyr304 | TDDDKNIyLTLPPND | phosphorylation up-regulates activity | 8756631 | SIGNOR-249312 |
| BLK | PLCG2 | – | phosphorylation up-regulates activity | 29545808 | SIGNOR-280195 | |
| BLK | FCGR2C | Tyr294 | YETADGGyMTLNPRA | phosphorylation up-regulates activity | 8756631 | SIGNOR-262672 |
| BLK | FCGR2C | Tyr310 | TDDDKNIyLTLPPND | phosphorylation up-regulates activity | 8756631 | SIGNOR-262673 |
| BLK | CGAS | Tyr215 | LLNTGSYyEHVKISA | phosphorylation down-regulates activity | 30356214 | SIGNOR-275844 |
| BLK | BCR-Mk | – | phosphorylation up-regulates activity | 32323266 | SIGNOR-268208 | |
| BLK | BCR-Ml | – | phosphorylation up-regulates activity | 32323266 | SIGNOR-268211 | |
| BLK | BCR-Dk | – | phosphorylation up-regulates activity | 32323266 | SIGNOR-268214 | |
| BLK | BCR-Dl | – | phosphorylation up-regulates activity | 32323266 | SIGNOR-268217 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BLK | phosphorylation up-regulates → | SOCS1 PTyr80 | phosphorylation down-regulates ⊣ | SOCS1 | 31101761 | SIGNOR-277889 |
| BLK | phosphorylation up-regulates → | FCGR2A PTyr288 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-249311 |
| BLK | phosphorylation up-regulates → | FCGR2A PTyr304 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-249312 |
| BLK | phosphorylation up-regulates → | FCGR2C PTyr294 | phosphorylation up-regulates → | FCGR2C | 8756631 | SIGNOR-262672 |
| BLK | phosphorylation up-regulates → | FCGR2C PTyr310 | phosphorylation up-regulates → | FCGR2C | 8756631 | SIGNOR-262673 |
| BLK | phosphorylation up-regulates → | CGAS PTyr215 | phosphorylation down-regulates ⊣ | CGAS | 30356214 | SIGNOR-275844 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BLK | phosphorylation → down-regulates activity | SOCS1 | SIGNOR-277889 |
| BLK | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-249311 |
| BLK | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-249312 |
| BLK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-280195 |
| BLK | phosphorylation → up-regulates activity | FCGR2C | SIGNOR-262672 |
| BLK | phosphorylation → up-regulates activity | FCGR2C | SIGNOR-262673 |
| BLK | phosphorylation → down-regulates activity | CGAS | SIGNOR-275844 |
| BLK | phosphorylation → up-regulates activity | BCR-Mk | SIGNOR-268208 |
| BLK | phosphorylation → up-regulates activity | BCR-Ml | SIGNOR-268211 |
| BLK | phosphorylation → up-regulates activity | BCR-Dk | SIGNOR-268214 |
| BLK | phosphorylation → up-regulates activity | BCR-Dl | SIGNOR-268217 |