| Name | DUSP3 |
| ID | P51452 |
| Role | phosphatase |
| Enzymatic Domains |
Tyrosine-protein phosphatase 28-179 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP3 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 21262974 | SIGNOR-248532 |
| DUSP3 | ERBB2 | Tyr1221 | SPAFDNLyYWDQDPP | dephosphorylation down-regulates activity | 21262974 | SIGNOR-248534 |
| DUSP3 | ERBB2 | Tyr877 | LDIDETEyHADGGKV | dephosphorylation down-regulates activity | 21262974 | SIGNOR-248533 |
| DUSP3 | NPM1 | – | dephosphorylation down-regulates activity | 33777934 | SIGNOR-277005 | |
| DUSP3 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10224087 | SIGNOR-248535 |
| DUSP3 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 12840032 | SIGNOR-103035 |
| DUSP3 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10224087 | SIGNOR-248536 |
| DUSP3 | STAT3 | – | dephosphorylation down-regulates activity | 32475380 | SIGNOR-277070 | |
| DUSP3 | PTK2 | – | dephosphorylation down-regulates activity | 28759036 | SIGNOR-277033 | |
| DUSP3 | ERK1/2 | – | dephosphorylation down-regulates activity | 10224087 | SIGNOR-269928 | |
| DUSP3 | Gbeta | – | dephosphorylation down-regulates activity | 10224087 | SIGNOR-269907 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP3 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 21262974 | SIGNOR-248532 |
| DUSP3 | dephosphorylation down-regulates ⊣ | ERBB2 PTyr1221 | dephosphorylation up-regulates → | ERBB2 | 21262974 | SIGNOR-248534 |
| DUSP3 | dephosphorylation down-regulates ⊣ | ERBB2 PTyr877 | dephosphorylation up-regulates → | ERBB2 | 21262974 | SIGNOR-248533 |
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 10224087 | SIGNOR-248535 |
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 12840032 | SIGNOR-103035 |
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 10224087 | SIGNOR-248536 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DUSP3 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248532 |
| DUSP3 | dephosphorylation → down-regulates activity | ERBB2 | SIGNOR-248534 |
| DUSP3 | dephosphorylation → down-regulates activity | ERBB2 | SIGNOR-248533 |
| DUSP3 | dephosphorylation → down-regulates activity | NPM1 | SIGNOR-277005 |
| DUSP3 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248535 |
| DUSP3 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-103035 |
| DUSP3 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248536 |
| DUSP3 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277070 |
| DUSP3 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-277033 |
| DUSP3 | dephosphorylation → down-regulates activity | ERK1/2 | SIGNOR-269928 |
| DUSP3 | dephosphorylation → down-regulates activity | Gbeta | SIGNOR-269907 |