Entity Details

Name DUSP3
ID P51452
Role substrate
Enzymatic Domains
Tyrosine-protein phosphatase 28-179
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ZAP70DUSP3Tyr138SPTLVIAyLMMRQKMphosphorylation
up-regulates		12447358SIGNOR-95877
TYK2DUSP3Tyr138SPTLVIAyLMMRQKMphosphorylation
up-regulates		17785772SIGNOR-157655
SYKDUSP3Tyr138SPTLVIAyLMMRQKMphosphorylation
up-regulates activity		12447358SIGNOR-275999
ZAP70DUSP3Tyr138SPTLVIAyLMMRQKMphosphorylation
up-regulates activity		12447358SIGNOR-276000
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ZAP70phosphorylation
up-regulates
→
DUSP3
PTyr138		phosphorylation
up-regulates
→		DUSP312447358SIGNOR-95877
TYK2phosphorylation
up-regulates
→
DUSP3
PTyr138		phosphorylation
up-regulates
→		DUSP317785772SIGNOR-157655
SYKphosphorylation
up-regulates
→
DUSP3
PTyr138		phosphorylation
up-regulates
→		DUSP312447358SIGNOR-275999
ZAP70phosphorylation
up-regulates
→
DUSP3
PTyr138		phosphorylation
up-regulates
→		DUSP312447358SIGNOR-276000
Regulator Mechanism/Effect Target SIGNOR-ID
ZAP70phosphorylation
→
up-regulates 		DUSP3SIGNOR-95877
TYK2phosphorylation
→
up-regulates 		DUSP3SIGNOR-157655
SYKphosphorylation
→
up-regulates activity 		DUSP3SIGNOR-275999
ZAP70phosphorylation
→
up-regulates activity 		DUSP3SIGNOR-276000