| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | DUSP3 | Tyr138 | SPTLVIAyLMMRQKM | phosphorylation up-regulates | 12447358 | SIGNOR-95877 |
| TYK2 | DUSP3 | Tyr138 | SPTLVIAyLMMRQKM | phosphorylation up-regulates | 17785772 | SIGNOR-157655 |
| SYK | DUSP3 | Tyr138 | SPTLVIAyLMMRQKM | phosphorylation up-regulates activity | 12447358 | SIGNOR-275999 |
| ZAP70 | DUSP3 | Tyr138 | SPTLVIAyLMMRQKM | phosphorylation up-regulates activity | 12447358 | SIGNOR-276000 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | phosphorylation up-regulates → | DUSP3 PTyr138 | phosphorylation up-regulates → | DUSP3 | 12447358 | SIGNOR-95877 |
| TYK2 | phosphorylation up-regulates → | DUSP3 PTyr138 | phosphorylation up-regulates → | DUSP3 | 17785772 | SIGNOR-157655 |
| SYK | phosphorylation up-regulates → | DUSP3 PTyr138 | phosphorylation up-regulates → | DUSP3 | 12447358 | SIGNOR-275999 |
| ZAP70 | phosphorylation up-regulates → | DUSP3 PTyr138 | phosphorylation up-regulates → | DUSP3 | 12447358 | SIGNOR-276000 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ZAP70 | phosphorylation → up-regulates | DUSP3 | SIGNOR-95877 |
| TYK2 | phosphorylation → up-regulates | DUSP3 | SIGNOR-157655 |
| SYK | phosphorylation → up-regulates activity | DUSP3 | SIGNOR-275999 |
| ZAP70 | phosphorylation → up-regulates activity | DUSP3 | SIGNOR-276000 |
